Efficacy of image-enhanced endoscopy for colorectal adenoma detection: A multicenter, randomized trial

Table 4 Overall adenoma detection rate in patients of the subgroup

	NBI group (n = 2016)	LCI group (n = 97)	WLI group (n = 2098)	P value1	RR (95%CI)	P value2	RR (95%CI)	P value3	RR (95%CI)
ADR	478/2016 (23.7)	30/97 (30.9)	458/2098 (21.8)	0.15	1.09 (0.97-1.22)	0.04	1.42 (1.04-1.93)	0.10	0.77 (0.56-1.04)
Advanced ADR	122/2016 (6.1)	5/97 (5.2)	116/2098 (5.5)	0.47	1.10 (0.86-1.40)	0.87	0.93 (0.39-2.23)	0.72	1.17 (0.49-2.80)
Diminutive ADR	304/2016 (15.1)	19/97 (19.6)	286/2098 (13.6)	0.19	1.11 (0.95-1.28)	0.10	1.44 (0.95-2.18)	0.23	0.77 (0.51-1.17)
ADR in different ages
< 50 yr	55/538 (10.2)	12/48 (25.0)	54/557 (9.7)	0.77	1.05 (0.74-1.51)	0.01	2.58 (1.49-4.48)	0.01	0.41 (0.24-0.71)
≥ 50 yr	423/1478 (28.6)	18/49 (36.7)	404/1541 (26.2)	0.14	1.09 (0.97-1.23)	0.10	1.40 (0.96-2.04)	0.22	0.78 (0.54-1.14)
ADR in different gender
Male	270/953 (28.3)	18/49 (36.7)	254/982 (25.9)	0.22	1.10 (0.95-1.27)	0.09	1.42 (0.97-2.08)	0.21	0.77 (0.53-1.13)
Female	208/1063 (19.6)	12/48 (25.0)	204/1116 (18.3)	0.44	1.07 (0.90-1.27)	0.24	1.37 (0.83-2.27)	0.36	0.78 (0.47-1.30)
ADR with different indications
Diagnostic
< 50 yr	23/247 (9.3)	3/23 (13.0)	23/256 (9.0)	0.90	1.04 (0.60-1.80)	0.464	1.45 (0.47-4.47)	0.474	0.71 (0.23-2.20)
≥ 50 yr	171/590 (29.0)	8/20 (40.0)	166/620 (26.8)	0.39	1.08 (0.90-1.30)	0.19	1.49 (0.86-2.60)	0.29	0.73 (0.42-1.26)
Surveillance
< 50 yr	8/96 (8.3)	1/8 (12.5)	7/93 (7.5)	0.84	1.11 (0.42-2.93)	0.504	1.66 (0.23-11.87)	0.534	0.67 (0.10-4.69)
≥ 50 yr	134/496 (27.0)	4/13 (30.8)	126/508 (24.8)	0.42	1.09 (0.88-1.34)	0.754	1.24 (0.54-2.84)	0.764	0.88 (0.38-2.01)
Screening
< 50 yr	24/195 (12.3)	8/17 (47.1)	24/208 (11.5)	0.81	1.07 (0.63-1.81)	0.01	4.08 (2.17-7.65)	0.014	0.26 (0.14-0.49)
≥ 50 yr	118/392 (30.1)	6/16 (37.5)	112/413 (27.1)	0.35	1.11 (0.89-1.38)	0.40	1.38 (0.72-2.65)	0.58	0.80 (0.42-1.54)
Withdrawal time	7.90 ± 3.46	7.82 ± 2.67	7.85 ± 3.47	0.47		0.02		0.05

¹The P value between narrow band imaging group and white light imaging group.

²The P value between linked color imaging group and white light imaging group.

³The P value between narrow band imaging group and linked color imaging group.

⁴Using fisher exact test.

Dates are n or n (%). ADR: Adenoma detection rate; RR: Relative risk; NBI: Narrow band imaging; WLI: White light imaging; LCI: Linked color imaging; CI: Confidence interval.