Epidemiology and outcome of individuals with intraductal papillary neoplasms of the bile duct

Table 1 Demographics and clinicopathologic characteristics of patients with invasive intraductal papillary neoplasm of the bile duct, n (%)

Variable	Total (n = 1635)	Subtype 1 (mucin)	Subtype 2 (non-mucin)
Age at diagnosis, yr		n = 926	n = 709
< 68	796 (48.7)	464 (50.1)	332 (46.8)
≥ 68	839 (51.3)	462 (49.9)	377 (53.2)
Sex
Male	896 (54.8)	504 (56.3)	392 (55.3)
Female	739 (45.2)	422 (45.6)	317 (44.7)
Race
White	1278 (78.2)	741 (80.0)	537 (75.7)
Black	116 (7.1)	67 (7.2)	49 (7.1)
Others	241 (14.7)	118 (12.7)	123 (17.3)
THM 7/CSv0204+ schema
Liver	100 (6.1)	90 (9.7)	10 (1.4)
Intrahepatic bile	99 (6.1)	87 (9.4)	12 (1.7)
Perihilar bile	600 (36.6)	304 (32.8)	296 (41.7)
Distal bile	53 (3.2)	27 (2.9)	26 (3.7)
Pancreaticobiliaryampulla	783 (47.9)	418 (45.1)	365 (51.5)
SEER historic stage
Localized	401 (24.5)	130 (14)	271 (38.2)
Regional	814 (49.8)	482 (52.1)	332 (46.8)
Distant	317 (19.4)	259 (28)	58 (8.2)
Unstaged	103 (6.3)	55 (5.9)	48 (6.8)
Grade
Well (I)	373 (22.8)	119 (12.9)	254 (35.8)
Moderately (II)	532 (32.5)	310 (33.5)	222 (31.3)
Poorly (III)	227 (13.8)	176 (19.0)	51 (7.2)
Undifferentiated (IV)	22 (1.3)	11 (1.2)	11 (1.6)
Unknown	481 (29.4)	310 (33.5)	171 (24.1)
Surgery
Performed	982 (60.1)	483 (52.2)	489 (70.4)
Defined radical surgery	579 (35.4)	336 (36.3)	243 (35.0)
Undefined radical surgery	375 (22.9)	130 (14.1)	235 (33.4)
Palliative surgery	28 (1.8)	17 (1.8)	11 (2.0)
Non	653 (39.9)	443 (47.8)	210 (29.6)
Radiatherapy
Performed	286 (17.5)	173 (18.7)	113 (15.9)
Non	1349 (82.5)	753 (81.3)	596 (84.1)
Chemotherapy
Performed	458 (28.0)	339 (36.6)	119 (16.8)
Non	1177 (72.0)	587 (63.4)	590 (83.2)

SEER: Surveillance, Epidemiology, and End Results database.