Lipid metabolism of hepatocellular carcinoma impacts targeted therapy and immunotherapy

Figure 2 Cholesterol metabolism in hepatocellular carcinoma. A: Cholesterol metabolic pathway diagram; B: Changes of cholesterol metabolism in hepatocellular carcinoma and related targets. ABCA: ATP binding cassette subfamily A; ACAT1: Acyl-CoA cholesterol acyltransferase 1; CEs: Cholesterol esters; Farnesyl PP: Farnesyl diphosphate; HMGCR: 3-hydroxy-3-methylglutaryl-CoA reductase; HMGCS: 3-hydroxy-3-methylglutaryl-CoA synthase; HSP90: Heat shock protein 90; LDLR: Low-density lipoprotein receptor; LXR: Liver X receptor; mSREBP2: Mature sterol regulatory element binding protein 2; PI3K: Phosphatidylinositol-3-kinase; PTEN: Phosphatase and tensin homolog deleted on Chromosome 10; SQLE: Squalene epoxidase; XBP-u: The unspliced X-box binding protein 1.