Lipid metabolism of hepatocellular carcinoma impacts targeted therapy and immunotherapy

doi:10.4251/wjgo.v15.i4.617

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Apr 15, 2023 (publication date) through Nov 23, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Apr 15, 2023; 15(4): 617-631
Published online Apr 15, 2023. doi: 10.4251/wjgo.v15.i4.617

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Figure 1 Fatty acid metabolism in hepatocellular carcinoma. A: Fatty acid metabolic pathway diagram; B: Changes of fatty acid metabolism in hepatocellular carcinoma and related targets. ACC: Acetyl- CoA carboxylase; ACLY: ATP citrate lyase; ACOX: Acyl-CoA oxidase 1; ACS: Acyl-CoA synthetases; CPT: Carnitine palmitoyl transfer; FASN: Fatty acid synthase; FA-CoA: Fatty Acyl-CoA; FFA: Free fatty acids; MCD: Malonyl-CoA decarboxylase; MUFA: Monounsaturated fatty acid; PPARα: Peroxisome proliferator-activated receptor α; TAC circle: Tricarboxylic acid cycle; SCD: Stearoyl-CoA desaturase; SIRT5: Sirtuin5; SREBP1c: Sterol-regulatory element binding protein 1c.

Citation: Feng XC, Liu FC, Chen WY, Du J, Liu H. Lipid metabolism of hepatocellular carcinoma impacts targeted therapy and immunotherapy. World J Gastrointest Oncol 2023; 15(4): 617-631
URL: https://www.wjgnet.com/1948-5204/full/v15/i4/617.htm
DOI: https://dx.doi.org/10.4251/wjgo.v15.i4.617