Correlation between immune-related adverse events and long-term outcomes in pembrolizumab-treated patients with unresectable hepatocellular carcinoma: A retrospective study

Table 2 Incidence of treatment-related adverse events

Adverse event	Any grade	Grade 3	Grade 4
Cutaneous toxic effects	25 (13.2)	3 (1.6)	2 (1.1)
Mucositis	8 (4.2)	2 (1.1)	1 (< 1)
Rash	7 (3.7)	1 (< 1)	1 (< 1)
Pruritus	10 (5.3)	2 (1.1)	0 (0)
Diarrhea	27 (14.2)	4 (2.1)	1 (< 1)
Elevated transaminases	35 (18.4)	10 (5.3)	2 (1.1)
Hypothyroidism	25 (13.2)	4 (2.1)	2 (1.1)
Myocarditis	3 (1.6)	1 (< 1)	2 (1.1)
Hypoadrenocorticism	5 (2.6)	1 (< 1)	0 (0)
Proteinuria	18 (9.5)	5 (2.6)	0 (0)
Overall incidence	138 (72.6)	12 (6.3)	7 (3.7)