Role of adjuvant chemotherapy on recurrence and survival in patients with resected ampulla of Vater carcinoma

Table 5 Adverse events during treatment

Adverse event	FL (n = 30)		FP (n = 22)		P value1
	Grade 1-2	Grade 3-4	Grade 1-2	Grade 3-4
Stomatitis	11 (36.7)	0	3 (13.6)	0	0.112
Nausea	6 (20.0)	0	19 (86.4)	0	< 0.001
Vomiting	1 (3.3)	0	4 (18.2)	0	0.149
Diarrhea	2 (6.6)	1 (3.3)	0	0	0.253
Fatigue	8 (26.7)	1 (3.3)	19 (86.4)	0	< 0.001
Neutropenia	3 (10.0)	0	10 (45.5)	4 (18.2)	< 0.001
Febrile neutropenia	0	0	0	2 (9.0)	0.174
Anemia	8 (26.7)	0	10 (45.5)	1 (4.5)	0.084
Thrombocytopenia	2 (6.6)	0	8 (36.4)	0	0.012
Increased AST/ALT level	4 (13.3)	0	0	0	0.128

¹Comparison of the proportion of all grades of adverse events. FL: Fluorouracil/leucovorin; FP: Fluorouracil/cisplatin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase.