Role of adjuvant chemotherapy on recurrence and survival in patients with resected ampulla of Vater carcinoma

Table 3 Univariate and multivariate analyses of the clinicopathologic findings and adjuvant chemotherapy for overall survival in patients with ampulla of Vater carcinoma

Variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age ≥ 70 yr (vs < 70 yr)	2.66 (1.40-5.07)	0.003	2.16 (1.18-3.98)	0.013
Histologic grade 3 (vs grade 1-2)	1.91 (0.67-5.49)	0.228	1.93 (0.77-4.81)	0.159
Tumor stage 3 or 4 (vs stage 1 or 2)	2.32 (1.31-4.11)	0.004	2.50 (1.31-4.80)	0.006
Nodal metastasis (vs none)	1.36 (0.77-2.39)	0.284	1.09 (0.58-2.04)	0.799
Lymphatic invasion (vs none)	1.50 (0.84-2.65)	0.168	1.23 (0.62-2.45)	0.553
Vascular invasion (vs none)	2.89 (1.35-6.20)	0.006	1.93 (0.96-3.88)	0.064
Perineural invasion (vs none)	2.17 (1.13-4.17)	0.020	1.27 (0.66-2.45)	0.477
Received AC (vs none)	1.04 (0.59-1.82)	0.018	0.58 (0.30-1.11)	0.098

HR: Hazard ratio; AC: Adjuvant chemotherapy.