Role of adjuvant chemotherapy on recurrence and survival in patients with resected ampulla of Vater carcinoma

Table 2 Univariate and multivariate analyses of the clinicopathologic findings and adjuvant chemotherapy for disease-free survival in patients with ampulla of Vater carcinoma

Variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age ≥ 70 yr (vs < 70 yr)	1.57 (0.91-2.70)	0.102
Histologic grade 3 (vs grade 1-2)	2.66 (0.98-7.18)	0.054	2.24 (1.02-4.95)	0.046
Tumor stage 3 or 4 (vs stage 1 or 2)	1.99 (1.21-3.28)	0.007	1.85 (1.06-3.22)	0.030
Nodal metastasis (vs none)	1.24 (0.76-2.03)	0.390	1.10 (0.63-1.95)	0.736
Lymphatic invasion (vs none)	1.76 (1.07-2.90)	0.025	1.49 (0.80-2.80)	0.212
Vascular invasion (vs none)	2.98 (1.53-5.80)	0.001	2.14 (1.20-3.79)	0.010
Perineural invasion (vs none)	1.47 (0.85-2.55)	0.164	0.97 (0.55-1.71)	0.901
Received AC (vs none)	0.85 (0.52-1.40)	0.536	0.50 (0.29-0.88)	0.015

HR: Hazard ratio; AC: Adjuvant chemotherapy.