Review
Copyright ©The Author(s) 2023.
World J Gastrointest Oncol. Apr 15, 2023; 15(4): 571-595
Published online Apr 15, 2023. doi: 10.4251/wjgo.v15.i4.571
Table 2 Clinical trials evaluating the impact of chemotherapeutic agents against specific targets
Target
Study treatment
Phase
Population
No. of patients
mPFS
mOS
Ref.
EGFRGEM + Erlotinib IIILocally advanced or metastatic PDAC2853.756.24Moore et al[10], 2007
GEM + Placebo2843.555.91
EGFRGEM + NimotuzumabIIbLocally advanced or metastatic PC965.18.6Schultheis et al[50], 2017
GEM + Placebo963.46
EGFRGEM + NimotuzumabIIIK-Ras wild-type, locally advanced or metastatic PC464.210.9Qin et al[51], 2022)
GEM + Placebo463.68.5
ERB2GEM + AfatinibIIMetastatic PC793.97.3Haas et al[57], 2021
GEM + Placebo403.97.4
VEGFGEM + axitinibIIAdvanced PC694.26.9Spano et al[67], 2008
GEM 343.75.6
VEGFGEM + axitinibIIIAdvanced PDAC3144.48.5Kindler et al[68], 2011
GEM + Placebo3164.48.3
VEGFGEM + afliberceptIIIMetastatic PC2713.76.5Rougier et al[69], 2013
GEM + Placebo2755.17.8
PARPVeliparibIIBRCA-mutated PDAC163.11.7Lowery et al[101], 2018
PARPOlaparibIIIgBRCA1 or BRCA2 mutation and metastatic PC927.418.9Golan et al[103], 2019
Placebo623.818.1
PARPCisplatin and GEM + Veliparib IIUntreated gBRCA/PALB2+ PDAC with measurable stage III to IV PDAC2710.115.5Sohal et al[40], 2020
Cisplatin and GEM 239.716.4
RETGEM + Vandetanib IILocally advanced or metastatic PC72NA8.83Middleton et al[107], 2017
GEM + Placebo708.95
HedgehogGEM + VismodegibIIMetastatic PC5346.9Catenacci et al[160], 2015
GEM + Placebo532.56.1
Hyaluronic acidmFOLFIRINOX + PEGPH20 IIMetastatic PDAC554.37.7Ramanathan et al[169], 2019
mFOLFIRINOX 596.214.4
MMPGEM + MarimastatNAAdvanced PC120NA5.51Bramhall et al[172], 2002
GEM + Placebo1195.47
MMPsTanomastatIIIAdvanced or Metastatic PDAC1381.683.74Moore et al[173], 2003
GEM1393.56.59
NOTCHRO4929097IIPreviously treated metastatic PDAC181.54.1De Jesus-Acosta et al[190], 2014
NOTCHGEM + TarextumabIIUntreated metastatic PC893.76.4Hu et al[193], 2019
GEM + Placebo885.57.9
WntGEM and nab-paclitaxel + IpafriceptIbUntreated stage IV PC265.99.7Dotan et al[196], 2020
AutophagyGEM and nab-paclitaxel + HydroxychloroquineIIAdvanced PC555.711.1Karasic et al[209], 2019
GEM and nab-paclitaxel 576.412.1