Possible mechanisms associated with immune escape and apoptosis on anti-hepatocellular carcinoma effect of Mu Ji Fang granules

Figure 7 Mu Ji Fang Granules alleviated the modulation of Transforming growth factor β1 inhibitor (LY364947) on the Transforming growth factor β1/ Mothers against decapentaplegic homolog signaling pathway, immune and apoptotic cytokines in HepG2 cells. A: Relative expression of Transforming growth factor β1(TGF-β1), Mothers against decapentaplegic homolog (SMAD) 2, p-SMAD2, SMAD4, and SMAD7 protein following treatment of HepG2 cells with TGF-β1 inhibitor (LY364947); B: Relative expression of Tumor necrosis factor α and Interferon gamma mRNA following treatment of HepG2 cells with TGF-β1 inhibitor (LY364947); C: Relative expression of Bax, and Bcl2 mRNA following treatment of HepG2 cells with TGF-β1 inhibitor (LY364947) (n = 4). Data are shown as mean ± standard deviation. ^aP < 0.01 vs Control [Mu Ji Fang Granules (MJF) 0 mg/mL]. ^bP < 0.05 vs Control [Mu Ji Fang Granules (MJF) 0 mg/mL]. ^cP < 0.01 vs Mu Ji Fang Granules 10 mg/mL. ^dP < 0.05 vs Mu Ji Fang Granules 10 mg/mL.