Cancerous inhibitor of protein phosphatase 2A enhances chemoresistance of gastric cancer cells to oxaliplatin

Figure 6 Downregulation of cancerous inhibitor of protein phosphatase 2A promoted oxaliplatin-related apoptosis in human gastric cancer cells. Control small interference RNA (siRNA) and cancerous inhibitor of protein phosphatase 2A (CIP2A) siRNA-transfected human gastric cancer cells were exposed to oxaliplatin (2 μg/mL). A: At 24 h after treatment, apoptosis was examined via annexin V/propidium iodide staining and flow cytometry; B and C: The percentage of apoptotic cells was quantitatively presented in MKN-45 (B) and AGS (C) cells. The results consisted of three independent tests. The cancerous inhibitor of protein phosphatase 2A siRNA group vs the control siRNA group. ^aP < 0.05. V-FITC: V-fluorescein 5-isothiocyanate.