Cancerous inhibitor of protein phosphatase 2A enhances chemoresistance of gastric cancer cells to oxaliplatin

Figure 1 Cancerous inhibitor of protein phosphatase 2A was highly expressed in gastric cancer tissues. A: Representative immunohistochemistry images of cancerous inhibitor of protein phosphatase 2A (CIP2A) in the adjacent normal gastric tissues and gastric cancer (GC) tissues (scale bar = 50 μm); B: The percentage of CIP2A^high expression was significantly higher in GC tissues than in adjacent normal gastric tissues; C: The mRNA expression levels of CIP2A were higher in 18 fresh frozen GC tissues than in matched adjacent normal gastric tissues; D: Western blot analysis showed that CIP2A expression level in tumor tissues (T) was significantly higher than that in adjacent normal tissues (N). Representative images were displayed in paired fresh surgical GC tissues; E and F: Based on data in The Cancer Genome Atlas (TCGA), including paired sample data and unpaired sample data (F), GC tissues had a higher CIP2A expression than adjacent normal gastric tissues. ^bP < 0.01. ^cP < 0.001.