Immune-related adverse events associated with immune checkpoint inhibitors for advanced gastric and gastroesophageal junction cancer: A meta-analysis

Table 3 Characteristics of the included case series studies

Case series	Enrollment size, n	Cancer types	ICIs	IrAEs, all grades, n	IrAEs, severe grades, n	mOS	mPFS
Suzuki et al[44], 2021 (Low ascites burden)	50	AGC	PD-1 (nivolumab)	9	1	5.3 mo (95%CI: 3.4 to 7.3 mo)	1.5 mo (95%CI: 1.0 to 2.0 mo)
Suzuki et al[44], 2021 (High ascites burden)	22	AGC	PD-1 (nivolumab)	5	0	2.5 mo (95%CI: 0 to 5.0 mo)	1.0 mo (95%CI: 0.9 to 1.1 mo)
Ohta et al[43], 2020	15	AGC	PD-1 (nivolumab)	5	0	6.3 mo	NA
Namikawa et al[42], 2020	29	AGC	PD-1 (nivolumab)	10	0	5.6 mo (95%CI: 0.6 to 26.8 mo)	2.3 mo (95%CI: 0.5 to 24.8 mo)
Kono et al[41], 2021	52	AGC	PD-1 (nivolumab)	13	1	7.9 mo (95%CI: 5.9 to 13.5 mo)	1.9 mo (95%CI: 1.4 to 3.0 mo)
Booka et al[40], 2021	50	GEA/ESCC	PD-1 (nivolumab)	13	5	NA	NA
Ando et al[39], 2021	108	AGC	PD-1 (nivolumab)	17	5	3.6 mo (95%CI: 3.0 to 5.3 mo)	1.4 mo (95%CI: 1.2 to 1.8 mo)

ICIs: Immune checkpoint inhibitors; irAEs: Immune-related adverse events; mOS: Median overall survival; mPFS: Median progression-free survival; NA: Not available; PD-1: Programmed cell death receptor-1; AGC: Advanced gastric cancer; GEA: Gastroesophageal adenocarcinoma; ESCC: Esophageal squamous cell carcinoma.