Cancerous inhibitor of protein phosphatase 2A enhances chemoresistance of gastric cancer cells to oxaliplatin

doi:10.4251/wjgo.v15.i2.286

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Feb 15, 2023 (publication date) through Feb 11, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Feb 15, 2023; 15(2): 286-302
Published online Feb 15, 2023. doi: 10.4251/wjgo.v15.i2.286

Table 2 Univariate and multivariate analyses of overall survival in patients with gastric cancer

Prognostic variables	Univariate analysis			Multivariate analysis
Prognostic variables	Hazard ratio	95% confidence interval	P value	Hazard ratio	95% confidence interval	P value
Sex	0.99	0.584–1.679	0.97	-	-	-
Age	1.372	0.820–2.296	0.229	-	-	-
Tumor location	0.925	0.545–1.569	0.772	-	-	-
Histological grade	0.736	0.420–1.288	0.283	-	-	-
Tumor size	2.417	1.399–4.176	0.004^a	0.87	0.504–1.504	0.619
T stage	3.184	1.687–6.007	0.000^a	2.651	1.295–5.423	0.008^a
N stage	2.034	1.196–3.457	0.009^a	1.414	0.709–2.818	0.325
TNM stage	1.946	1.168–3.243	0.011^a	0.912	0.469–1.774	0.786
CIP2A expression	2.319	1.288–3.927	0.003^a	1. 802	1.012–3.210	0.046^a

^aP < 0.05.

T: Tumor; N: Node; TNM: Tumor Node Metastasis; CIP2A: Cancerous inhibitor of protein phosphatase 2A.

Citation: Zhao YX, Ma LB, Yang Z, Wang F, Wang HY, Dang JY. Cancerous inhibitor of protein phosphatase 2A enhances chemoresistance of gastric cancer cells to oxaliplatin. World J Gastrointest Oncol 2023; 15(2): 286-302
URL: https://www.wjgnet.com/1948-5204/full/v15/i2/286.htm
DOI: https://dx.doi.org/10.4251/wjgo.v15.i2.286