Role of ferroptosis in colorectal cancer

Table 1 Key molecular targets and inducers involved in the regulation of colorectal cancer ferroptosis

Target	Ferroptosis inducers	Ref.
ACSL4	Bromelain	[35]
	Apatinib	[37]
	Emodin	[36]
SLC7A11	Erastin	[42]
	SAS	[44,45]
	Talaroconvolutin A	[50]
	Copper chelator elesclomol	[51]
	IMCA	[52]
	Pt3R5G	[53]
	RSV	[54]
Transsulfuration pathway	CARS	[65]
	VZnO	[66]
GPX4	Erastin	[67]
	RSL3	[67]
	ACADSB	[79]
Nrf2/HO-1	Cetuximab	[87]
	Lys	[90]
	Oxaliplatin	[94,95]
Cellular iron homeostasis	HIF-2α	[102]
	miR-545	[104]
	Dichloroacetate	[105]
	IREB2	[106]
P53	Ginsenoside Rh4	[113]
	Cullin-9	[114]

ACSL4: Acyl-CoA synthetase long-chain family member 4; SLC7A11: Solute carrier family 7 member 11; SAS: Sulphasalazine; IMCA: Benzopyran derivative 2-imino-6-methoxy-2H-chromene-3-carbothioamide; Pt3R5G: Petunidin 3-O-[rhamnopyranosyl-(trans-p-coumaroyl)]-5-O-(β-D-glucopyranoside); RSV: Resveratrol; CARS: Cysteinyl-tRNA synthetase; RSL3: Ras-selective lethal 3; Nrf2: Nuclear factor erythroid 2-related factor; HO-1: Haem oxygenase 1; Lys: Lysionotin; IREB2: Iron response element-binding protein 2; GPX4: Glutathione peroxidase 4; HIF-2α: Hypoxia-inducible factor-2α.