Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms: A bioinformatics study

Figure 6 Identification of heat shock factor protein 4 methylation-related genes and their enrichment analysis in colorectal cancer. A: Volcano plot showing genes positively and negatively associated with heat shock factor protein 4 (HSF4) methylation in colorectal cancer. B, C: Expression profiles of the top 50 genes ranked by absolute correlation coefficient of HSF4 methylation-related genes. B is the expression profile of genes positively associated with HSF4 methylation; C is the expression profile of genes negatively associated with HSF4 methylation. D: Bubble plots exhibiting the GO enrichment results of all HSF4 methylation-related genes. E: Possible pathways involved in HSF4 methylation-related genes obtained by Kyoto Encyclopedia of Genes and Genomes enrichment analysis. HSF4: Heat shock factor protein 4; BP: Biological process; CC: Cell component; MF: Molecular function; PD-L1: Programmed cell death-Ligand 1; PD-1: Programmed death 1; IL-17: Interleukin-17.