Hsa_circ_0136666 mediates the antitumor effect of curcumin in colorectal carcinoma by regulating CXCL1 via miR-1301-3p

Figure 8 Overexpressing hsa_circ_0136666 abolished the repression of curcumin on colorectal carcinoma growth in vivo. The nude mice were subcutaneously inoculated with SW480 introduced with vector or oe-hsa_circ_0136666, followed by intraperitoneal curcumin (25 mg/kg) injection one week later. A and B: Tumour volume and tumour weight measurements in the xenografts; C: Real-time quantitative PCR assay quantification of hsa_circ_0136666, miR-1301-3p, and CXCL1 in xenografts; D: Western blot assay of CXCL1 protein in xenografts; E: Immunohistochemical staining of Ki-67 and proliferating cell nuclear antigen expression in xenografts. ¹P < 0.05. PCNA: Proliferating cell nuclear antigen.