Association of MBOAT7 rs641738 polymorphism with hepatocellular carcinoma susceptibility: A systematic review and meta-analysis

Table 2 Studies included in meta-analysis

Ref.	Country	Cohort characteristics	Cases	Controls	Genotype (CC/CT/TT)		Allele (C/T)		Minor allele frequency		Adjustment	HWE of control (P value)
					Case	Control	Case	Control	Case	Control
Thabet et al[8], 2016	Multi	HCV-related HCC	75	1706	24/35/16	531/822/353	83/67	1884/1528	0.45 (T)	0.45 (T)	Age, gender, BMI, and Child-Pugh score	0.305
Donati et al[9], 2017	Italian	NAFLD-related HCC	132	633	26/69/37	213/285/135	121/143	711/555	0.46 (C)	0.44 (T)	Age, gender, obesity, T2DM, and presence of advanced fibrosis	0.036
Donati et al[9], 2017	Italian & United Kingdom	Non-cirrhotic NAFLD-related HCC	41	872	5/21/15	280/422/170	31/51	982/762	0.38 (C)	0.44 (T)	NA	0.664
Donati et al[9], 2017	Italian	HCV-related HCC	13	584	1/7/5	177/259/148	9/17	613/555	0.35 (C)	0.48 (T)	Age, gender, and genetic variants	0.009
Donati et al[9], 2017	Italian	Alcohol-related HCC	12	512	1/8/3	150/251/111	10/14	551/473	0.42 (C)	0.46 (T)	Age, gender, and genetic variants	0.805
Stickel et al[11], 2018	Switzerland, Germany & United Kingdom	Alcohol-related cirrhotic HCC	751	1165	203/363/185	314/583/268	769/733	1211/1119	0.49 (T)	0.48 (T)	Age, gender, BMI, and T2DM	0.967
Raksayot et al[14], 2019	Thailand	HBV-related HCC	270	105	140/114/16	66/34/5	394/146	166/44	0.27 (T)	0.21 (T)	NA	0.943
Raksayot et al[14], 2019	Thailand	HCV-related HCC	131	105	71/53/7	66/34/5	195/67	166/44	0.26 (T)	0.21 (T)	NA	0.943
Raksayot et al[14], 2019	Thailand	NBNC-related HCC (containing NAFLD and alcoholic liver disease)	129	105	68/46/15	66/34/5	182/76	166/44	0.30 (T)	0.21 (T)	NA	0.943
Wang et al[16], 2021	China	Unspecified	779	1405	426/295/58	800/528/77	1147/411	2128/682	0.26 (T)	0.24 (T)	Age, gender, smoking status, and drinking status	0.437
Bianco et al[12], 2021	Italian & United Kingdom	NAFLD-related HCC	226	2338	NA	NA	NA	NA	NA	NA	Age, gender, BMI, and T2DM	NA
Bianco et al[12], 2021	United Kingdom	UKBB (Non-viral)	202	363,846	NA	NA	NA	NA	NA	NA	Age, gender, BMI, T2DM, ethnicity, array batch, and assessment center	NA

HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma; HWE: Hardy-Weinberg equilibrium; NAFLD: Nonalcoholic fatty liver disease; HBV: Hepatitis B virus; T2DM: Type 2 diabetes mellitus; BMI: Body mass index; UKBB: United Kingdom BioBank; NBNC: Non-hepatitis B and non-hepatitis C; NA: Not available.