Evaluating the causal relationship between human blood metabolites and gastroesophageal reflux disease

Table 2 Genetic predictors of butyrylcarnitine and their association with GERD

SNP	Gene	CHR	A1	A2	Butyrylcarnitine			GERD
					Beta	SE	P value	Beta	SE	P value
rs10849832	OASL	12	C	T	0.0499	0.0067	1.06E-13	0.0106	0.0083	0.2040
rs10849846	P2RX7	12	C	T	0.0511	0.0097	1.34E-07	0.0079	0.0115	0.4916
rs11065202	CABP1	12	C	T	-0.1297	0.004	1.00E-200	-0.0087	0.0049	0.0751
rs11065208	MLEC	12	A	G	-0.0683	0.0106	1.17E-10	-0.0075	0.0134	0.5745
rs11065270	SPPL3	12	C	T	0.0603	0.0069	1.65E-18	0.0198	0.0091	0.0298
rs1109732	RP11-210L7.1	12	A	G	-0.0606	0.014	1.47E-05	-0.0004	0.0187	0.9848
rs1171617	SLC16A9	10	T	G	0.0358	0.0047	1.61E-14	0.0049	0.0057	0.3849
rs1186055	P2RX7	12	C	A	-0.0344	0.0043	1.30E-15	-0.0042	0.0054	0.4358
rs12025912	KIF17	1	C	T	0.0228	0.0053	1.76E-05	-0.0005	0.0069	0.9418
rs12255141	VTI1A	10	A	G	-0.0272	0.0062	1.15E-05	-0.0093	0.0081	0.2478
rs12257526	GRID1	10	C	T	0.0248	0.0058	1.74E-05	0.0105	0.0074	0.1580
rs12368199	OASL	12	A	G	0.1211	0.0052	1.67E-121	0.0062	0.0067	0.3564
rs12562686	RP11-410C4.4	1	A	C	-0.036	0.0084	1.74E-05	-0.0014	0.0103	0.8883
rs1336584	CTA-21C21.1	1	C	T	-0.018	0.0042	1.91E-05	-0.0079	0.0049	0.1064
rs1469231	NECAP1P1	7	A	G	-0.0188	0.0043	1.00E-05	-0.0098	0.0053	0.0653
rs1557852	RNA5SP192	5	G	A	-0.0181	0.0042	1.53E-05	-0.0067	0.0051	0.1904
rs17050084	AC007131.2	2	C	T	-0.0413	0.0096	1.90E-05	-0.0270	0.0123	0.0274
rs17507671	RNU4-1	12	C	T	-0.0512	0.0096	1.03E-07	0.0036	0.0108	0.7423
rs17686203	WAC	10	C	T	-0.0518	0.0118	1.06E-05	0.0118	0.0142	0.4093
rs1873745	C8orf37-AS1	8	A	G	-0.0195	0.0044	1.01E-05	-0.0098	0.0059	0.0972
rs1955919	LINC01765	1	A	G	-0.0467	0.0106	1.13E-05	-0.0253	0.0123	0.0389
rs1957910	PRKCH	14	A	G	0.0376	0.0088	1.96E-05	-0.0046	0.0093	0.6255
rs208294	-	-	-	-	0.0315	0.0036	1.08E-18	0.0058	0.0048	0.2293
rs2631693	FSIP1	15	C	G	-0.0233	0.0053	1.14E-05	-0.0085	0.0071	0.2302
rs273914	SLC22A4	5	T	A	0.0236	0.0041	1.17E-08	0.0016	0.0050	0.7519
rs278136	CIT	12	C	T	-0.0259	0.0043	1.96E-09	0.0040	0.0057	0.4776
rs3767512	CACNA1S	1	A	G	0.0625	0.0146	1.91E-05	0.0252	0.0177	0.1544
rs3817190	CAMKK2	12	A	T	0.0249	0.0047	1.14E-07	-0.0008	0.0049	0.8770
rs4146382	AC019050.1	2	C	T	-0.0186	0.0043	1.25E-05	-0.0001	0.0052	0.9912
rs4766962	COX6A1	12	A	T	0.0516	0.0043	1.70E-33	0.0078	0.0051	0.1238
rs4767937	SPPL3	12	C	G	0.1052	0.0035	1.00E-200	0.0142	0.0048	0.0032
rs4870883	FER1L6	8	A	T	-0.0262	0.006	1.41E-05	0.0057	0.0053	0.2824
rs4943508	LINC01048	13	C	T	0.0153	0.0035	1.38E-05	0.0098	0.0048	0.0431
rs646454	SGO1-AS1	3	T	C	0.0257	0.0059	1.17E-05	-0.0079	0.0074	0.2851
rs6468765	KB-1410C5.3	8	C	T	0.0156	0.0035	1.02E-05	-0.0078	0.0049	0.1082
rs6496996	RN7SL599P	15	A	G	0.0197	0.0045	1.05E-05	0.0035	0.0060	0.5583
rs7295193	TMEM117	12	C	T	-0.0288	0.0067	1.58E-05	0.0115	0.0088	0.1884
rs7303401	HNF1A-AS1	12	A	T	-0.0692	0.006	1.38E-30	-0.0106	0.0077	0.1678
rs7954772	SLC38A4	12	A	T	0.0182	0.0042	1.22E-05	-0.0009	0.0050	0.8617
rs7979473	HNF1A	12	G	A	0.0184	0.0042	1.20E-05	0.0078	0.0050	0.1184

GERD: Gastroesophageal reflux disease; SNP: Single nucleotide polymorphism; CHR: Chromosome.