Identification of genes associated with gall bladder cell carcinogenesis: Implications in targeted therapy of gall bladder cancer

doi:10.4251/wjgo.v15.i12.2053

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Dec 15, 2023; 15(12): 2053-2063
Published online Dec 15, 2023. doi: 10.4251/wjgo.v15.i12.2053

Table 2 Target genes for treating gall bladder cancer (under investigation and those under clinical trial)

Target genes silenced by siRNA (under investigation)	Target genes for GBC treatment (under clinical trial)
BMI1, CD44, CLIC1, JAB1, EGFR	EGFR and Her/2 together (Afatnib-NCT04183712, Apatinib-NCT03702491)
HER 2/neu, ARAF	HER/2 (Trastuzumab-NCT00478140)
MIF	MEK (Trametinib-NCT02042443)
CD73, PDL1	DNMT (Guadecitabine-NCT03257761)

GBC: Gall bladder cancer.

Citation: Ghosh I, Dey Ghosh R, Mukhopadhyay S. Identification of genes associated with gall bladder cell carcinogenesis: Implications in targeted therapy of gall bladder cancer. World J Gastrointest Oncol 2023; 15(12): 2053-2063
URL: https://www.wjgnet.com/1948-5204/full/v15/i12/2053.htm
DOI: https://dx.doi.org/10.4251/wjgo.v15.i12.2053