Dopamine and cyclic adenosine monophosphate-regulated phosphoprotein with an apparent Mr of 32000 promotes colorectal cancer growth

Figure 5 Dopamine and cyclic adenosine monophosphate regulated phosphoprotein with an apparent Mr of 32000 promotes colorectal cancer cell invasion and migration. A and B: By using the wound healing assay, dopamine and cyclic adenosine monophosphate regulated phosphoprotein with an apparent Mr of 32000 (DARPP-32) overexpression improved the ability of HCT116 and SW480 cells to migrate; C and D: By using a wound healing experiment, DARPP-32 knockdown reduced the ability of HT-29 and LOVO cells to migrate; E and F: Images illustrating the capacity for cell migration and invasion in HCT116 and SW480 cells where DARPP-32 overexpression was found in the transwell assay; G and H: Images illustrating the capacity for cell migration and invasion in HT-29 and LOVO cells where DARPP-32 knockdown was found in the transwell assay (black scale bars, 100 μm). ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. NC: Negative control.