Dopamine and cyclic adenosine monophosphate-regulated phosphoprotein with an apparent Mr of 32000 promotes colorectal cancer growth

Figure 1 Expression and clinical relevance of dopamine and cyclic adenosine monophosphate regulated phosphoprotein with an apparent Mr of 32000 in colorectal cancer. A: Dopamine and cyclic adenosine monophosphate regulated phosphoprotein with an apparent Mr of 32000 (DARPP-32) mRNA level in primary human colorectal cancer (CRC) tumors (n = 376) and normal tissues (n = 667) were analyzed from the Gene Expression Profiling Interactive Analysis Database; B: DARPP-32 expression was validated in 70 pairs of CRC patient samples by polymerase chain reaction; C-E: Representative images and quantification of DARPP-32 staining in 94 CRC tissues and 86 normal tissues (red scale bars, 200 μm; black scale bars, 50 μm); F: Overall survival curves for CRC patients expressing DARPP-32 according to Kaplan-Meier curves; G-I: DARPP-32’s mRNA and protein levels in cell lines (NCM460, HCT116, SW480, HT-29, LOVO). ^aP < 0.05; ^bP < 0.01; ^cP < 0.001.