Role of inositol polyphosphate-4-phosphatase type II in oncogenesis of digestive system tumors

Figure 2 Molecular mechanism of inositol polyphosphate-4-phosphatase type II in cancer proliferation through the phosphoinositide 3-kinase/serum and glucocorticoid-regulated kinase 3 pathway. PI(3)P, produced by inositol polyphosphate-4-phosphatase type II, can bind to and activate serum and glucocorticoid-regulated kinase 3, which promotes the occurrence and development of tumors and resists the process of apoptosis of tumor cells. INPP4B: Inositol polyphosphate-4-phosphatase type II; PI3K: Phosphoinositide 3-kinase; SGK3: Serum and glucocorticoid-regulated kinase 3.