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©The Author(s) 2023.
World J Gastrointest Oncol. Oct 15, 2023; 15(10): 1706-1716
Published online Oct 15, 2023. doi: 10.4251/wjgo.v15.i10.1706
Published online Oct 15, 2023. doi: 10.4251/wjgo.v15.i10.1706
Figure 2 Molecular mechanism of inositol polyphosphate-4-phosphatase type II in cancer proliferation through the phosphoinositide 3-kinase/serum and glucocorticoid-regulated kinase 3 pathway.
PI(3)P, produced by inositol polyphosphate-4-phosphatase type II, can bind to and activate serum and glucocorticoid-regulated kinase 3, which promotes the occurrence and development of tumors and resists the process of apoptosis of tumor cells. INPP4B: Inositol polyphosphate-4-phosphatase type II; PI3K: Phosphoinositide 3-kinase; SGK3: Serum and glucocorticoid-regulated kinase 3.
- Citation: Han L, Chen S, Du SY. Role of inositol polyphosphate-4-phosphatase type II in oncogenesis of digestive system tumors. World J Gastrointest Oncol 2023; 15(10): 1706-1716
- URL: https://www.wjgnet.com/1948-5204/full/v15/i10/1706.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v15.i10.1706