Synchronous occurrence of gastric cancer and gastrointestinal stromal tumor: A case report and review of the literature

Table 3 Details of the clinical, histological, immunohistochemical, and outcomes of concurrent gastric cancer and gastrointestinal stromal tumor summarized in this study and literature review

Ref.	Sex	Age in yr	GC					GIST					Outcome
			Location	Size (cm)	TNM status	Lauren	Differentiation	Location	Size (cm)	Risk	CD117	CD34
Maiorana et al[6], 2000	F	81	Cardias	4.0	T2bN0M0, IB	Intestinal	NA	Fundus	5.0	L	NA		21 m, DOD
	F	79	Antrum	2.0	T1bN0M0, IA	Diffuse		Pylorus	6.0	H		+	54 m, PFS
	M	75	Antrum	4.0	T2bN1M0, IIA	Intestinal		Antrum	5.0	L			12 m, PFS
	F	79	Pylorus	1.2	T2aN1M0, IIA	Intestinal		Cardias	5.0	L		+	28 m, PFS
	M	79	Antrum	2.0	T2aN0M0, IB	Intestinal		Cardias	0.6	V-L		+	75 m, PFS
Bircan et al[7], 2004	71	Antrum	5.7	T3NxM0	Intestinal	P	Cardias	0.5	V-L	+	+	NA	71
	77	Cardias	7.5	T2N1M0, IIA	NA	M	Cardias	0.6	V-L	+	+	NA	77
Villias et al[8], 2008	M	78	Antrum	NA	T1N0M0, IA	Intestinal	M	Antrum	0.9	V-L	+	+	NA
Lin et al[9], 2006	F	70	Cardias	1.7	T1N0M0, IA	NA	P, SRCC	Fundus	1.1	V-L	+	+	14 m, PFS
Liu et al[10], 2018	M	72	Antrum	4.0	T2N1M0, IIA	NA	M	Fundus	2.0	V-L	+	+	18 m, PFS
Wronski et al[11], 2006	F	64	Antrum	5.0	T4N0M0, IIB	Diffuse	NA	Cardias	2.0	L	+	+	NA
	M	66	Cardias	1.0	T1N0M0, IA	Intestinal	NA	Cardias	1.0	V-L	+	+	NA
Theodosopoulos et al[63], 2011	M	80	Antrum	6.5	T1N0M0, IA	Intestinal	W	Body	3.0	IN	+	NA	12 m, PFS
Rauf et al[46], 2006	F	70	Antrum, body	10.0.	T4N1M0, IIIA	Diffuse	P, SRCC	Body	2.0	L	+	+	18 m, DOD
Namikawa et al[14], 2021	M	74	Body	2.0	T2N0M0, IB	NA	M	Body	2.2	L	NA	NA	1 m, PFS
Shimodate et al[15], 2014	M	79	Body	3.0	T1bN0M0, IA	NA	NA	Body	1.3	V-L	+	+	NA
Khoshnevis et al[16], 2013	F	64	Pylorus	6.0	T4N0M0, IIIA	Diffuse	P, SRCC	Fundus, body	1.0	H	+	NA	4 m, PFS
Namikawa et al[17], 2016	M	58	Body	9.0	T2N1M0, IIA	Diffuse	SRCC	Body	21.0	H	NA	NA	4 m, PFS
Kaffes et al[18], 2002	M	78	Antrum	NA	T1N0M0, IA	Diffuse	P	Body	1.5	ND	NA	+	20 m, PFS
Uchiyama et al[19], 2007	M	74	Antrum	1.5	T1aN0M0, IA	Intestinal	M-P	Body	0.8	L	+	+	NA
Salemis et al[20], 2008	F	78	Antrum	6.5	T4N2M0, IIIA	Diffuse	P	Body	1.0	L	+	+	14 m, DOD
Narasimhamurthy et al[21], 2010	M	65	Cardias	4.0	T4NxM0	Diffuse	P	Antrum	2.5	L	+	NA	NA
Ferreira et al[22], 2010	M	52	NA	10.2	T3N1M0, IIB	NA	NA	NA	1.1	V-L	+	+	NA
	F	65	NA	4.8	T3N1M0, IIB	NA	NA	NA	0.7	V-L	+	+
Gonçalves et al[23], 2010	M	74	NA	NA	NA	NA	NA	NA	1.2	V-L	NA	NA	5 m, DOD
	M	67	NA	NA	NA	NA	NA	NA	0.3	V-L	NA	NA	2 m, DOD
Jeong et al[24], 2011	M	74	Antrum	3.3	T1aN0M0, IA	Intestinal	M	Body	2.0	V-L	+	+	NA
Cai et al[25], 2013	M	47	Cardias	8.0	T3N1M0, IIB	NA	P	Cardias	2.0	V-L	+	+	NA
	M	80	Antrum	2.0	T1N0M0, IA		P	Cardias	1.5	V-L	+	+
	M	60	Antrum	8.0	T3N0M0, IIA			Antrum	0.6	V-L	+	+
	F	67	Antrum	4.0	T3N1M0, IIB			Body	0.8	V-L	+	+
	M	78	Pylorus	6.0	T4N2M0, IIIA			Body	2.5	L	+	+
	M	78	Body	10.0	T3N1M0, IIB			Body	1.4	L	+	+
	F	59	Body	4.0	T2N1M0, IIA		P	Body	0.8	L	+	+
	M	80	Antrum	6.0	T2N0M0, IB		P	Body	5.0	L	+	+
Liszka et al[26], 2007	M	53	NA	NA	NA	NA	NA	NA	NA	V-L	+	NA	NA
	M	63	NA	NA	NA	NA	NA	NA	NA	L	+	NA
Yamamoto et al[27], 2012	M	67	Body	3.0	T4N0M0, IIB	Diffuse	P	Body	3.0	L	+	+	NA
Gülpınar et al[28], 2014	M	75	Antrum	NA	T1N1M0, IB	NA	M	Antrum	1.0		NA	NA	NA
Trihia et al[29], 2019	M	79	Cardias	8.5	NA	Intestinal	M-P	Body	0.9	L	+	+	Days, DOD
Yan et al[30], 2013	M	53	U	NA	T4N0M0, IIIA	NA	P	NA	0.4	V-L	NA		NA
	M	51	U	NA	T4N3M0, IIIB		M-P		0.8	V-L	+
	M	62	U	NA	T4N2M0, IIIA		P		0.8	V-L	NA
	F	73	L	NA	T4N3M0, IIIB		P, SRCC		0.2	V-L	NA
	M	68	M	NA	T1N0M0, IA		M		0.8	V-L	NA
	F	46	L	NA	T1bN0M0, IA		P, SRCCM		2.5	L	+
	M	78	U	NA	T4N1M0, IIIA		M		1.5	V-L	+
	M	66	U	NA	T4N3M0, IIIB		M-P		1.5	V-L	+
	M	85	U, M	NA	T4N2M0, IIIA		P		1.0	V-L	+
	M	68	L	NA	T4N0M0, IIB		M		0.8	V-L	+
	M	69	U	NA	T4N0M0, IIB		P, SRCC		2.0	V-L	+
	M	77	U	NA	T2N1M0, IIA		M		0.2	V-L	+
	M	71	L	NA	T4N3M0, IIIB		M-P		0.6	V-L	+
	F	77	L	NA	T4N3M0, IIIB		M-P		0.5	V-L	+
	F	70	L	NA	T1bN0M0, IA				0.6	V-L	+
Vogel et al[31], 2011	M	79	Body	6.0	T1N0M0, IA	Diffuse	P, SRCC	Body	0.8	V-L	+	NA	12 m, PFS
1Ozgun et al[32], 2009	M	78	Body	NA	NA	NA	NA	Antrum	10.0	H	+	+
Hsiao et al[33], 2009	M	75	Cardias	1.0	T1N0M0, IA	NA	W	Cardias	3.3	L	+	+	6 m, DOD
Kountourakis et al[34], 2008	F	72	NA	NA	NA	Diffuse	NA	NA	1.8	V-L	+	+	6 m, PFS
Lee et al[35], 2007	M	82	Body	9.5	T4NxM1, IV	NA	NA	Body	1.5	L	+	+	NA
Chen et al[36], 2001	M	72	Pylorus	1.5	NA	NA	NA	Body	2.5	V-L	+	+	NA
1Katsoulis et al[37], 2007	F	78	Cardias	NA	T4N3aM0, IIIB	Diffuse	P	Antrum	0.9	V-L	+	NA	NA
1Liu et al[38], 2002	M	70	Cardia, fundus	8.5	T4N0M1, IV	Intestinal	NA	Cardia	NA	V-L	+	+	3 m, DOD
1Toyoda et al[39], 2009	F	83	Body	9.0	T4NxM0	Intestinal	P	Body	4.5	H	+	+	6 m, DOD
1Matsuno et al[40], 2021	M	68	Body	5.0	T3N0M0, IIA	NA	M	Body	0.5	V-L	+	NA	2.5 yr, PFS
1Kleist et al[41], 2010	F	86	Body	6.0	NA	Intestinal	SRCC	Body	6.0	IN	+	+	11 m, PFS
	M	78	Body	6.0	NA	NA	SRCC	Body	5.5	IN	+	+	4 m, DOD
1Trabelsi et al[42], 2008	M	54	NA	NA	NA	Diffuse	NA	NA	1.0	V-L	NA	NA	NA
1Zámecník et al[64], 2005	F	93	Fundus	NA	LGIN, 0	NA	NA	Fundus	4.5	L	+	+	NA
1Idema et al[43], 2008	M	71	Body	5.0	T4N2M0, III A	Intestinal	SRCC	Body	0.6	V-L	+	+	30 m, DOD
Alkaaki et al[65], 2018	M	55	Cardia	1.7	T1aNxM0	NA	NA	Antrum	10	H	-	+	NA
1Bi et al[66], 2009	F	73	Fundus, body	4.0	T4N2M0, III A	Intestinal	W	Fundus	4	L	+	+	NA
1Firat et al[44], 2010	M	63	Cardia	9.0	T4N3bM0, IIIB	Intestinal	NA	Cardia	0.4	V-L	+	+	13 m, DOD
	M	60	Body	4.0	T1N0M0, IA	Intestinal		Body	0.5	V-L	+	+	12 m, PFS
Telugu et al[67], 2016	M	63	Cardia	4.0	T3N1M0, IIB	NA	M	Fundus	1.0	V-L	-	+	7 m, PFS
Lin et al[45], 2014	M (32), F (10)	> 60 (30), ≤ 60 (12)	NA	NA	IA (14), IB (8), IIA (5), IIB (1), IIIA (7), IIIB (4), III C (3)	NA	W (6), M (21), P (10), SRCC (5)	U (14), M (20), L (8)	≤ 2 (35), 2-5 (7)	V-L (35), L (4), IN (2), H (1)	+ (28)	+ (25)	3-yr (62.6), 5-yr (57.8%)
Liu et al[52], 2009	M (19), F (3)	64.5, (Med)	NA	NA	NA	NA	NA	Cardias (1), fundus (7), body (13), antrum (1)	0.8 (Med)	< L			5-yr (31.8%)
Present study	M (17), F (2)	62 (Med)	U (5), M (6), L (7), W (1)	3.5 (Med)	0 (1), IA (3), IB (3), IIA (3), IIB (3), III A (4), IIIC (2)	Diffuse (6), intestinal (5), mixed (3)	M-P (7), M (5), P (5), W (1)	Body (8), fundus (3), antrum (2), Cardia (2)	1.4 (Med)	L (10), V-L (7), H (2)	+ (19)	+ (18), - (1)	3-yr (73.9%), 5-yr (59.2%)
All	M (122), F (35)	70 (Med)	U (26), M (23), L (35)	4 (Med)	0 (2), IA (33), IB (16), IIA (17), IIB (13), IIIA (21), IIIB (11), IIIC (5), IV (2)	Diffuse (19), intestinal (23), mixed (3)	M-P (13), M (38), P (45), W (10)	U (43), M (66), L (20)	1.2 (Med)	V-L (84), L (35), IN (5), H (9)	- (2)	- (1)	3-yr (54.5%), 5-yr (46.7%)

¹Collision tumor.

GC: Gastric cancer; GIST: Gastrointestinal stromal tumor; M: Male; F: Female; Med: Median; DOD: Dead of disease; U: Upper one-third of the stomach; M: Middle one-third of the stomach; L: Lower one-third of the stomach; LGIN: Low-grade intraepithelial neoplasia; M-P: Moderately to poorly differentiated; M: Moderately differentiated; P: Poorly differentiated; W: Well differentiated; SRCC: Signet-ring cell carcinoma; V-L: Very low; L: Low; IN: Intermediate; H: High; SRCC: Signet-ring cell carcinoma; NA: Not assessed; PFS: Progression-free survival; pTNM: Pathological tumor-node-metastasis.