Association between the Khorana risk score and all-cause mortality in Japanese patients with gastric and colorectal cancer: A retrospective cohort study

Table 3 Multivariate analysis of the association between Khorana risk score and all-cause death within 2 years

Variable	Crude mode		Multivariable-adjusted model 1		Multivariable-adjusted model 2		Multivariable-adjusted model 3
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Trend test1	1.63 (1.38-1.93)	< 0.001	1.62 (1.37-1.92)	< 0.001	1.39 (1.10-1.76)	0.005	1.42 (1.12-1.8)	0.004
KRS, low-risk group	1 (Ref)		1 (Ref)		1 (Ref)		1 (Ref)
KRS, intermediate-risk group	1.6 (1.21-2.13)	0.001	1.6 (1.20-2.12)	0.001	1.43 (1.00-2.04)	0.047	1.45 (1.02-2.06)	0.041
KRS, high-risk group	2.67 (1.91-3.73)	< 0.001	2.64 (1.89-3.69)	< 0.001	1.95 (1.22-3.12)	0.005	2.02 (1.26-3.24)	0.004

¹A test for linear trend was performed for each model.

Multivariable-adjusted model 1: Adjusted for age and sex; Multivariable-adjusted model 2: Adjusted for age, sex, cancer-associated thrombosis (CAT), Eastern Cooperative Oncology Group (ECOG PS), cancer type, primary site surgery, adjuvant chemotherapy, active cancer and central venous catheter (CVC); Multivariable-adjusted model 3: Adjusted for age, sex, CAT, ECOG PS, cancer type, pathological type, primary site surgery, adjuvant chemotherapy, active cancer, single or multiple primary, CVC, thrombosis treatment, opportunity for diagnosis. KRS: Khorana risk score; HR: Hazard ratios; CI: Confidence intervals.