Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p/METTL3 regulatory axis

Figure 1 The expression and significance of circ_0001658 in colorectal cancer. A: The microarray data set GES172229 available from Gene Expression Omnibus data showed the differences in circular RNAs (circRNAs) expression in colorectal cancer (CRC) tissues and paracancerous tissues, with a volcanic map drawn; B: Heat map displayed the partially up-regulated circRNAs in CRC tissue; C: Circ_0001658 expression in CRC tissues and paracancerous tissues of 42 cases were under the detection of quantitative real-time polymerase chain reaction; D-E: The sensitivity of circ_0001658 to RNase digestion was detected by RNase-R assay. ^bP < 0.01; ^cP < 0.001. ns: No significance; DW: Down; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase.