Copyright
©The Author(s) 2023.
World J Gastrointest Oncol. Jan 15, 2023; 15(1): 19-35
Published online Jan 15, 2023. doi: 10.4251/wjgo.v15.i1.19
Published online Jan 15, 2023. doi: 10.4251/wjgo.v15.i1.19
Compound or Chinese herbal medicine or formula | Cell line/animal/human | Molecular mechanism | Effect and outcome | Ref. |
Astragaloside IV | Huh7, MHCC97-H | Modulate Akt/GSK-3β/β-catenin pathway. ↑E-cadherin. ↓N-cadherin, vimentin, α-Smooth Muscle Actin, Slug | ↓EMT, invasion, migration | Qin et al[66] |
Camptothecin | Huh7 | Modulate ZO-1, E-cadherin, claudin-1 | ↓EMT, metastasis | Liu et al[57] |
Isoviolanthin | HepG2, BEL-7402 | ↓TGF-β1. ↓TGF-β/SMAD and PI3K/Akt/mTOR pathway. ↓MMP-2 and -9 | ↓EMT | Xing et al[67] |
18β-Glycyrrhetinic Acid | BEL-7402, LM3 | Modulate. SHP1&SHP2/STAT3/Snail pathway. ↓Phosphorylation of STAT3. ↑SHP1 and SHP2 | ↓EMT and metastasis | Jie et al[68] |
Echinacea purpurea | Hepa1-6, HepG2, L-02 | Modulate PI3K/Akt pathway | ↓EMT | Xu et al[69] |
Tetrandrine | Huh7, Hep3B | ↓Wnt/β-catenin pathway. ↓Metastatic tumor antigen 1 | ↓EMT, invasion, migration | Zhang et al[70] |
Scorpion | Hepa1-6/Sprague-Dawley rats (6-wk, male, 0.63 g/200 g, every day for 4 wk) | ↑E-cadherin. ↓N-cadherin | ↓EMT, migration, invasion | Yan et al[71] |
Myricetin | MHCC97-H | ↑E-cadherin expression. ↓N-cadherin | ↓Migration, invasion | Ma et al[72] |
Hydroxygenkwanin | HepG2 and Huh7/nude mice (6-wk, male, 1 mg/kg for 3 times per week) | ↑miR-320a, ↓Forkhead box protein M1 | ↓EMT, invasion, migration. ↓Tumor size | Chou et al[73] |
Oleanolic acid | HepG2, SK-Hep-1 | ↑miR-122, E-cadherin. ↓β-catenin, N-cadherin, vimentin | ↓EMT, migration, invasion | He et al[74] |
Aloin | -- | Modulate circ_0011385/miR-149-5p/WT1 axis | ↓Invasion | Fu et al[50] |
Puerarin | BEL-7402, Huh7, L-02 | ↑PTEN. Modulate miR-21/PTEN/EMT axis | ↓EMT, migration, invasion | Zhou et al[75] |
Corylin | Hep G2, Huh7/nude mice (BALB/cAnN-Foxnlnu/CrlNarl, 6-wk, male, 60 mg/kg, 3 times per week) | ↑GAS5 | ↓EMT. ↓Tumor size | Chen et al[76] |
Kaempferol | Huh7, SK-Hep-1 | ↓MMP-9 and Akt pathway | ↓Migration | Ju et al[77] |
Dulcitol | HepG2 | ↓MMP-2, uPA, MMP-9. ↑E-cadherin | ↓Migration and invasion | Lin et al[78] |
Sanguisorba officinalis | HepG2 | Modulate EGFR, PI3K/AKT, NF-κB and MAPK pathway | ↓Migration, invasion | Jiang et al[52] |
Zanthoxylum avicennae | HA22T | ↑PP2Acα, GSK-3β, APC, β-TrCP/HOS. ↓β-catenin, p-GSK-3β, TBX 3, IL-8. ↓Nuclear and cytosolic β-catenin | ↓Metastasis | Wu et al[79] |
Bufalin | MHCC97-H | ↑TBK1, IRF3 and NF-κB pathway | ↓Migration, invasion | Feng et al[80] |
QHF (consisting of HuaChanSu, 20(R)ginseng saponin Rg3, notoginseng total saponin and lentinan) | HepG2 | ↑p38, JNK, MAPK pathway. ↓ERK pathway | ↓Migration, invasion | Chen et al[81] |
QHF (consisting of cinobufotalin, ginsenoside Rg3, panax notoginsenosides, lentinan) | HCCLM3, HepG2/SPF BALB/c mice (20 g, male, 0.2 ml/mice, once every other day for 4 wk) | ↓p-c-Met protein. ↓HGF/c-Met pathway | ↓Metastasis, invasion | Yuan et al[82] |
Biejiajian pill | MHCC-97H, SMMC-7721/BALB/c nude mice (4-5 wk, female, 1.1 g/kg, daily for 4 wk) | ↓Akt/GSK-3β/Snail pathway | ↓EMT, metastasis | Sun et al[83] |
Jiedu Recipe | SMMC-7721, Huh7 | ↑E-cadherin. ↓p-Smad2/3, Smad2/3. ↓TGF-β1, vimentin, N-cadherin, MMP2/9 | ↓EMT, invasion, migration | Liang et al[84] |
Xiaoai Jiedu Recipe | Male nude mice (BALB/c (nu/nu), 4–5 wk, male, 10 g/kg, 4 consecutive days). 40 HCC patients and 40 volunteer controls | Modulate miRNA-29a signal transducer ↑Transcription 3 Axis | ↓Metastasis | Shi et al[85] |
- Citation: Lai HC, Lin HJ, Jeng LB, Huang ST. Roles of conventional and complementary therapies in recurrent hepatocellular carcinoma. World J Gastrointest Oncol 2023; 15(1): 19-35
- URL: https://www.wjgnet.com/1948-5204/full/v15/i1/19.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v15.i1.19