Rs3746444 T>C locus in miR-499 increases the susceptibility to hepatocellular carcinoma: A meta-analysis 14812 subjects

Table 3 Summary of results of the meta-analysis from different comparative genetic model

Genetic comparison	Population	OR (95%CI)	P value	Test of heterogeneity		Model	Power value
				P value	I2
C vs T	All	1.21 (1.03-1.41)	0.019	< 0.001	74.9%	R	1.000
	Ethnicity
	Asians	1.32 (1.06-1.64)	0.013	< 0.001	79.4%	R	1.000
	Caucasians	1.06 (0.86-1.32)	0.586	0.010	64.2%	R	-
	Study design
	HB	1.25 (1.01-1.54)	0.039	< 0.001	79.0%	R	0.999
	PB	1.13 (0.90-1.42)	0.285	0.027	63.6%	R	-
	Controls
	Normal or healthy control	1.22 (1.02-1.48)	0.034	< 0.001	77.2%	R	0.998
	Hepatitis or virus related control	1.27 (1.07-1.52)	0.007	0.192	39.4%	F	0.785
	NA	0.71 (0.49-1.04)	0.080	-	-	-	-
	Nos quality assessment
	≥ 7.0	1.24 (0.97-1.58)	0.088	< 0.001	81.2%	R
	< 7.0	1.17 (0.96-1.43)	0.216	0.004	66.2%	R
CC vs TT	All	1.33 (0.98-1.80)	0.071	0.002	57.3%	R	-
	Ethnicity
	Asians	1.48 (0.97-2.26)	0.073	0.021	54.0%	R	-
	Caucasians	1.16 (0.72-1.87)	0.534	0.008	65.3%	R	-
	Study design
	HB	1.44 (0.97-2.16)	0.074	< 0.001	67.7%	R	-
	PB	1.20 (0.83-1.73)	0.344	0.551	0.0%	F	-
	Controls
	Normal or healthy control	1.31 (0.88-1.93)	0.183	0.001	62.8%	R	-
	Hepatitis or virus related control	1.56 (1.10-2.23)	0.014	0.329	10.1%	F	0.725
	NA	0.47 (0.12-1.87)	0.285	-	-	-	-
	Nos quality assessment
	≥ 7.0	1.26 (0.71-2.25)	0.436	0.02	67.3%	R
	< 7.0	1.41 (1.01-1.96)	0.014	0.086	43.8%	R	0.881
CC/CT vs TT	All	1.26 (1.04-1.51)	0.016	< 0.001	70.0%	R	0.999
	Ethnicity
	Asians	1.34 (1.06-1.71)	0.016	< 0.001	75.7%	R	0.999
	Caucasians	1.12 (0.83-1.51)	0.468	0.021	59.7%	R	-
	Study design
	HB	1.32 (1.03-1.70)	0.031	< 0.001	73.1%	R	0.999
	PB	1.16 (0.87-1.54)	0.309	0.014	67.9%	R	-
	Controls
	Normal or healthy control	1.29 (1.03-1.60)	0.024	< 0.001	72.5%	R	0.999
	Hepatitis or virus related control	1.37 (1.06-1.77)	0.018	0.397	0.0%	F	0.697
	NA	0.68 (0.44-1.05)	0.084	-	-	-	-
	Nos quality assessment
	≥ 7.0	1.33 (1.01-1.76)	0.044	< 0.001	78.2%	R	0.997
	< 7.0	1.18 (0.92-1.51)	0.191	0.026	56.1%	R
CC vs TT/CT	All	1.21 (0.96-1.53)	0.109	0.049	39.4%	R	-
	Ethnicity
	Asians	1.37 (0.95-1.97)	0.095	0.077	42.1%	R	-
	Caucasians	1.09 (0.87-1.37)	0.448	0.127	39.6%	F	-
	Study design
	HB	1.25 (0.93-1.70)	0.145	0.014	53.7%	R	-
	PB	1.15 (0.80-1.65)	0.449	0.640	0.0%	F	-
	Controls
	Normal or healthy control	1.18 (0.87-1.60)	0.284	0.029	47.5%	R	-
	Hepatitis or virus related control	1.36 (0.99-1.87)	0.061	0.421	0.0%	F	-
	NA	0.53 (0.14-2.10)	0.368	-	-	-	-
	Nos quality assessment
	≥ 7.0	1.08 (0.68-1.71)	0.744	0.027	53.7%	R
	< 7.0	1.30 (1.05-1.60)	0.017	0.284	18.5%	F	0.734

Bold values are statistically significant (P < 0.05). F: Indicates fixed model; R: Indicates random model; PB: Population-based; HB: Hospital-based; NA: Not available; OR: Odds ratio; CI: Confidence interval; NOS: Newcastle-Ottawa Scale.