Rs3746444 T>C locus in miR-499 increases the susceptibility to hepatocellular carcinoma: A meta-analysis 14812 subjects

Table 1 Characteristics of the studies in meta-analysis

Ref.	Country	Ethnicity	Study design	Sex, male (%); case/control	Mean age (yr); case/control	Smoking (%); case/control	Drinking (%); case/control	HBsAg, positivee (%); case/control	Number cases/controls	Type of control	Case			Control			HWE
											TT	TC	CC	TT	TC	CC
Zhang et al[59], 2016	China	Asian	HB	70.29/56.29	56.13/54.96	34.29/30.79	50.29/36.09	NA	175/302	Normal or healthy control	115	49	11	197	87	18	0.052
Li et al[60], 2015	China	Asian	PB	75.56/75.56	≥ 55 yr, 55.26/≥55 yr, 53.38	36.47/31.58	47.37/36.47	41.35/12.03	266/250	Normal or healthy control	150	92	24	166	83	17	0.140
Yan et al[61], 2015	China	Asian	PB	77.74/63.41	≥ 55 yr, 55.84/≥ 55 yr, 45.43	47.81/42.68	58.76/40.55	61.31/10.37	274/328	Normal or healthy control	147	98	29	188	112	28	0.060
Qi et al[62], 2014	China	Asian	PB	83.8/83.8	50.7/49.6	38.9/NA	27.4/NA	83.2/0.0	314/406	Normal or healthy control	195	117	2	301	101	4	0.157
Chu et al[63], 2014	China	Asian	HB	72.34/74.78	< 45 yr, 5.05, 45-59 yr, 30.85, ≥ 60 yr, 63.83/< 45 yr, 7.12, 45-59 yr, 40.06, ≥ 60 yr, 52.82	42.55/33.23	36.17/40.36	42.55/13.23	188/337	Normal or healthy control	119	60	9	281	55	1	0.321
Zhou et al[64], 2012	China	Asian	PB	82.8/NA	52.1/NA	NA/NA	NA/NA	NA/NA	186/483	Normal or healthy control	141	41	4	371	100	12	0.100
Xiang et al[65], 2012	China	Asian	HB	82/39	48.55/47.02	NA/NA	NA/NA	NA/NA	100/100	Hepatitis or virus related control	36	40	24	52	35	13	0.081
Xiang et al[65], 2012	China	Asian	HB	82/50	48.55/45.12	NA/NA	NA/NA	NA/NA	100/100	Normal or healthy control	36	40	24	54	36	10	0.284
Kim et al[40], 2012	Korea	Asian	PB	NA/NA	NA/NA	NA/NA	NA/NA	NA/NA	159/201	NA/NA	109	47	3	120	74	7	0.278
Zhang et al[48], 2020	China	Asian	HB	89.90/90.47	53.17/53.72	35.96/35.43	29.11/16.03	70.55/9.21	584/923	Normal or healthy control	409	154	12	669	230	22	0.673
Toraih et al[50], 2016	Egypt	Caucasian	HB	NA/NA	NA/NA	NA/NA	NA/NA	NA/NA	60/150	Normal or healthy control	28	23	9	57	66	27	0.307
Fteah et al[56], 2019, Abdel-Hamid et al[57], 2018	Egypt	Caucasian	HB	80.00/81.33	50.12/50.11	54.7/0.0	NA/NA	NA/NA	75/75	Normal or healthy control	41	32	2	31	30	14	0.175
	Egypt	Caucasian	HB	78.0/70.0	55.8/54.4	34.0/34.0	NA/NA	6.0/0.0	50/50	Normal or healthy control	3	32	15	16	23	11	0.617
Al-Qahtani et al[58], 2017	Saudi Arabia	Caucasian	HB	NA/68.4	NA/40.29	NA/NA	NA/NA	NA/100.00	145/585	Hepatitis or virus related control	48	70	27	219	273	93	0.607
Al-Qahtani et al[58], 2017	Saudi Arabia	Caucasian	HB	NA/79.7	NA/36.33	NA/NA	NA/NA	NA/100.00	145/222	Hepatitis or virus related control	48	70	27	87	100	35	0.486
Al-Qahtani et al[58], 2017	Saudi Arabia	Caucasian	HB	NA/94.25	NA/37.49	NA/NA	NA/NA	NA/0.0	145/400	Normal or healthy control	48	70	27	148	187	65	0.647
Al-Qahtani et al[58], 2017	Saudi Arabia	Caucasian	HB	NA/96.30	NA/30.80	NA/NA	NA/NA	NA/0.0	145/600	Normal or healthy control	48	70	27	216	291	93	0.758

PB: Population-based; HB: Hospital-based; NA: Not available; HBsAg: Hepatitis B surface antigen; HWE: Hardy-Weinberg equilibrium.