Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data

Figure 5 Protein inhibitor of activated STAT 4 and SH3 domain, and nuclear localization signals 1 potential role in homeobox A10 have only been recently described and much remains to be understood. Ingenuity pathway analysis analysis demonstrated activation of protein inhibitor of activated STAT 4, and activation of downstream genes implicated in epithelial-mesenchymal transition through LEF1 and protocadherin 9. Our analysis also demonstrated inhibition of SH3 domain, and nuclear localization signals 1 with downstream effects on viral recognition and regulation of cell survival. Legend illustrates relationship between genes. See legend of Figure 3 for classification of genes. ALB: Albumin; FABP1: Fatty acid binding protein 1; MARCO: Macrophage receptor with collagenous structure; FGL2: Fibrinogen like 2; SAMSN1: SAM domain, SH3 domain and nuclear localization signals 1; USP12: Ubiquitin-specific protease 12; PIAS4: Protein inhibitor of activated STAT protein gamma; PCDH9: Protocadherin 9; LEF1: Lymphoid enhancer-binding factor 1; TLR3: Toll-like receptor 3. Citation: Figures produced from IPA are available under an open-access CC-BY 4.0 license for purposes of publication. The authors have obtained the permission for figure using from the QIAGEN Digital Insights (Supplementary material).