Clinicopathological characterization of ten patients with primary malignant melanoma of the esophagus and literature review

Figure 1 Imaging and microphotograph of primary malignant melanoma of the esophagus. A: Barium swallow examination showed an irregular filling defect on the lower third of the esophagus, causing mucosa destruction; B: Computed tomography showed an eccentric thickening in the lower third of the esophagus wall, with enhancement; C and D: Esophagoscopy revealed a nonpigmented polypoid tumor with hyperemia and erosion in the lower esophagus, and black lesion scattered on the wall of esophagus; E: Hematoxylin-eosin staining identified malignant melanoma cells in the lamina propria of the esophagus (× 100); F: Immunohistochemical staining with HMB45 (human melanoma black 45) antibody revealed positive tumor cells (× 100).