Prognostic and clinicopathological value of Twist expression in esophageal cancer: A meta-analysis

Table 3 Correlations of Twist expression with clinicopathological characteristics in esophageal cancer

Clinical features	RR (95%CI)	Heterogeneity test (I2)	P value	Number of studies
Age (≥ 60 vs < 60)	1.07 (0.95-1.21)	5.88	0.319	6
Gender (male vs female)	1.02 (0.89-1.18)a	14.85	0.062	9
Location (upper + middle vs lower)	0.89 (0.80-1.00)	4.66	0.199	4
T stage (T3 + T4 vs T1 + T2)	1.38 (1.14-1.67)a	15.30	0.018	7
Differentiation (high + moderate vs low)	0.94 (0.81-1.09)a	21.26	0.003	8
Lymph node metastasis (yes vs no)	1.34 (1.11- 1.60)a	14.99	0.036	8
Distant metastasis (yes vs no)	1.18 (1.02-1.35)a	10.74	0.030	5
TNM stage (III + IV vs I + II)	1.35 (1.14-1.60)a	13.34	0.038	7
Clinical stage (III + IV vs I + II)	1.58 (1.34-1.87)	0.39	0.534	2
Venous invasion (yes vs no)	1.46 (0.83-2.56)a	4.49	0.034	2

^aIf I² ≥ 50% and/or P < 0.1, random effects models are applied.

TNM: Tumor, node and metastasis.