Prognostic and clinicopathological value of Twist expression in esophageal cancer: A meta-analysis

doi:10.4251/wjgo.v14.i9.1874

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World Journal of Gastrointestinal Oncology

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Meta-Analysis

World J Gastrointest Oncol. Sep 15, 2022; 14(9): 1874-1886
Published online Sep 15, 2022. doi: 10.4251/wjgo.v14.i9.1874

Table 2 Meta-analyses for the association of Twist expression with survival of esophageal cancer

Meta-analysis	Endpoints	HR (95%CI)	Heterogeneity test (I²)	P value	Number of studies
TWIST (+) vs TWIST (−)	OS	1.88 (1.32-2.69)^a	68.6%	0.000	11
TWIST (+) vs TWIST (−)	DFS/RFS/PFS	1.84 (1.12-3.02)^a	67.1%	0.028	4
Method of quantification	Multiply percentage score and intensity score	1.52 (0.87-2.65)	79.5%	0.319	6
	Intensity score	2.72 (1.84-4.03)^a	0.00	0.062	9
	Percentage of stained cells	2.45 (1.43-4.19)^a	68.6%	0.199	4

^aIf I²≥ 50% and/or P < 0.1, random effects models are applied.

HR: Hazard ratio; OS: Overall survival; DFS: Disease-free survival; RFS: Relapse-free survival; PFS: Progression-free survival.

Citation: Song WP, Wang SY, Zhou SC, Wu DS, Xie JY, Liu TT, Wu XZ, Che GW. Prognostic and clinicopathological value of Twist expression in esophageal cancer: A meta-analysis. World J Gastrointest Oncol 2022; 14(9): 1874-1886
URL: https://www.wjgnet.com/1948-5204/full/v14/i9/1874.htm
DOI: https://dx.doi.org/10.4251/wjgo.v14.i9.1874