Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data

doi:10.4251/wjgo.v14.i9.1856

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Sep 15, 2022 (publication date) through Mar 31, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Meta-Analysis

World J Gastrointest Oncol. Sep 15, 2022; 14(9): 1856-1873
Published online Sep 15, 2022. doi: 10.4251/wjgo.v14.i9.1856

Table 1 Summary of the most up and down-regulated genes from the meta-analysis of primary tumor samples from hepatocellular carcinoma patients, experimental log ratios indicating magnitude of change from control samples are shown

Top upregulated		Top downregulated
GPC3	2.426	CLEC4G	-4.212
ANLN	2.398	CLEC1B	-4.122
CCNB1	2.239	LINC01092	-3.834
ASPM	2.220	SLCO1B3	-3.788
CDK1	2.215	CLEC4M	-3.689
NEK2	2.121	HAMP	-3.657
EPS8L3	2.116	STAB2	-3.604
PBK	2.017	OIT3	-3.575
DTL	2.010	MT1M	-3.508
PRC1	1.993	HHIP	-3.417

GPC3: Glypican 3; ANLN: Anillin; CCNB1: Cycline B1; ASPM: Abnormal spindle-like microcephaly-associated protein; CDK1: Cyclin-dependent kinase 1; NEK2: NIMA related kinase 2; EPS8L3: Epidermal growth factor receptor kinase substrate 8-like protein 3; PBK: PDZ binding kinase; DTL: Denticleless E3 ubiquitin protein ligase homolog; PRC1: Protein regulator of cytokinesis 1; CLEC4G: C-type lectin domain family 4 member G; CLEC1B: C-type lectin domain family 1 member B; LINC01092: Long intergenic non-protein coding RNA 1092; SLCO1B3: Solute carrier organic anion transporter family member 1B3; CLEC4M: C-type lectin domain family 4 member M; HAMP: Hepcidin; STAB2: Stabilin 2; OIT3: Oncoprotein induced transcript 3; MT1M: Metallothionein 1M; HHIP: Hedgehog interacting protein.

Citation: Aljabban J, Rohr M, Syed S, Cohen E, Hashi N, Syed S, Khorfan K, Aljabban H, Borkowski V, Segal M, Mukhtar M, Mohammed M, Boateng E, Nemer M, Panahiazar M, Hadley D, Jalil S, Mumtaz K. Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data. World J Gastrointest Oncol 2022; 14(9): 1856-1873
URL: https://www.wjgnet.com/1948-5204/full/v14/i9/1856.htm
DOI: https://dx.doi.org/10.4251/wjgo.v14.i9.1856