Endoscopic debulking resection with additive chemoradiotherapy: Optimal management of advanced inoperable esophageal squamous cell carcinoma

Table 3 Univariate and multivariate Cox regression analyses on overall survival and progression-free survival

Characteristics	OS, n = 41				PFS, n = 41
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Clinical stage (> IIB vs ≤ IIB)	18.908 (4.629-77.235)	0.000	18.908 (4.629-77.235)	0.000	11.311 (3.397-37.622)	0.000	11.311 (3.397-37.622)	0.000
Intervention (EdR vs EdR + CRT)	4.861 (1.213-19.487)	0.026		0.198		0.063		0.411
T stage (≥ 2 vs < 2)	68.037 (0.304-15204.04)	0.126			66.824 (0.505-8840.4)	0.092
N stage (≥ 1 vs 0)	13.329 (3.309-53.7)	0.000		0.737	4.937 (1.621-15.031)	0.005		0.318
M stage (≥ 1 vs 0)	9.13 (1.82-45.775)	0.007		0.876	7.035 (1.481-33.418)	0.014		0.906
Margin (positive/vague vs negative)	7.281 (0.84-63.144)	0.072				0.258

CRT: Chemoradiotherapy; EdR: Endoscopic debulking resection; OS: Overall survival; PFS: Progression-free survival.