Clinicopathological characterization of ten patients with primary malignant melanoma of the esophagus and literature review

Table 4 Univariate and multivariate analyses of predictive factors for overall survival and disease-free survival in patients with primary malignant melanoma of esophagus

Variable	Overall survival				Disease-free survival
	Uni-P	Multi-P	HR	95%CI	Uni-P	Multi-P	HR	95%CI
Gender
Male vs female	0.08				0.450
Age (yr)
< 55 vs ≥ 55	0.348				0.353
Tumor location
Upper vs middle vs lower	0.647				0.385
Tumor number
Single vs multiple	0.200				0.227
Tumor size (cm)
< 5.5 vs ≥ 5	0.282				0.124
Gross classification
Superficial vs polypoid vs ulcerative and others	0.04	0.249			0.007	0.893
Depth of invasion
T1a vs T1b vs T2 and T3 and T4	0.001	0.005	1.70	1.17-2.47	0.02	0.02	1.93	1.09-3.42
LNM
No vs yes	< 0.001	0.009	1.78	1.15-2.74	0.07
pTNM stage
I vs II vs III and IV	< 0.001	0.349			0.02	0.540
Treatment
Surgery vs surgery plus adjuvant therapy	0.433				0.02	0.698

LNM: Lymph node metastases; pTNM: Pathological tumor node metastasis; HR: Hazard ratio; CI: Confidence interval.