Prognostic impact of tumor deposits on overall survival in colorectal cancer: Based on Surveillance, Epidemiology, and End Results database

doi:10.4251/wjgo.v14.i9.1699

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. Sep 15, 2022; 14(9): 1699-1710
Published online Sep 15, 2022. doi: 10.4251/wjgo.v14.i9.1699

Table 4 Univariable Cox analysis in patients with and without tumor deposits

	TDs (no)			TDs (yes)			RHR	P value
	Events/total	HR (95%CI)	P value	Events/total	HR (95%CI)	P value	RHR	P value
Sex			0.1265			0.0528
Female	14534/43569	Reference		4474/6855	Reference
Male	15631/46055	1.02 (1.00-1.04)	0.1265	4727/7276	0.96 (0.92-1.00)	0.0528
Race			< 0.0001^a			< 0.0001
White	23736/70019	Reference		7222/11015	Reference
Black	3904/10345	1.16 (1.12-1.20)	< 0.0001^a	1145/1681	1.06 (1.00-1.13)	0.0536	0.91 (0.85-0.98)	0.0118^a
Others	2525/9260	0.79 (0.76-0.82)	< 0.0001^a	834/1435	0.83 (0.77-0.89)	< 0.0001^a	1.05 (0.97-1.14)	0.2380
Age group, yr			< 0.0001^a			< 0.0001^a
< 45	1201/5740	Reference		665/1231	Reference
45-75	15238/58860	1.26 (1.19-1.34)	< 0.0001^a	5718/9387	1.23 (1.13-1.33)	< 0.0001^a	0.98 (0.88-1.08)	0.6384
≥ 75	13726/25024	3.37 (3.18-3.58)	< 0.0001^a	2818/3513	2.34 (2.15-2.55)	< 0.0001^a	0.69 (0.63-0.77)	< 0.0001^a
TNM-stage			< 0.0001^a			< 0.0001^a
Ι	4683/24816	Reference		26/111	Reference
ΙΙ	8962/29374	1.77 (1.70-1.83)	< 0.0001^a	372/825	2.40 (1.61-3.57)	< 0.0001^a	1.36 (0.91-2.02)	0.1362
ΙΙΙ	9545/26627	2.17 (2.09-2.24)	< 0.0001^a	3953/7697	3.05 (2.08-4.49)	< 0.0001^a	1.41 (0.96-2.07)	0.0836
ΙV	6975/8807	8.05 (7.76-8.36)	< 0.0001^a	4850/5498	9.25 (6.29-13.6)	< 0.0001^a	1.15 (0.78-1.69)	0.4840
T-stage			< 0.0001^a			< 0.0001^a
T1	2726/15480	Reference		68/181	Reference
T2	3321/14312	1.35 (1.29-1.42)	< 0.0001^a	156/482	0.84 (0.63-1.11)	0.2246	0.62 (0.47-0.83)	0.0012^a
T3	17029/47654	2.30 (2.20-2.39)	< 0.0001^a	4533/7890	1.84 (1.45-2.34)	< 0.0001^a	0.80 (0.63-1.02)	0.0602
T4	7089/12178	4.84 (4.63-5.05)	< 0.0001^a	4444/5578	3.69 (2.90-4.68)	< 0.0001^a	0.76 (0.60-0.97)	0.0286^a
N-stage			< 0.0001^a			< 0.0001^a
N0	15350/56512	Reference		664/1247	Reference
N1	8434/22127	1.53 (1.49-1.57)	< 0.0001^a	3765/6582	1.14 (1.05-1.24)	0.0014^a	0.75 (0.68-0.81)	< 0.0001^a
N2	6381/10985	2.86 (2.77-2.94)	< 0.0001^a	4772/6302	1.99 (1.83-2.16)	< 0.0001^a	0.70 (0.64-0.76)	< 0.0001^a
M-stage			< 0.0001^a			< 0.0001^a
M0	23190/80817	Reference		4351/8633	Reference
M1	6975/8807	4.90 (4.77-5.04)	< 0.0001^a	4850/5498	3.13 (3.00-3.27)	< 0.0001^a	0.64 (0.61-0.67)	< 0.0001^a
Site			< 0.0001^a			< 0.0001^a
Colon	24983/71779	Reference		7791/11679	Reference
Rectum	4595/16603	0.74 (0.71-0.76)	< 0.0001^a	1187/2148	0.66 (0.62-0.71)	< 0.0001^a	0.89 (0.83-0.96)	0.0030^a
CEA			< 0.0001^a			< 0.0001^a
Normal	7926/32166	Reference		1782/3543	Reference
Elevated	9908/20936	2.34 (2.27-2.41)	< 0.0001^a	4190/5705	1.95 (1.84-2.06)	< 0.0001^a	0.83 (0.78-0.89)	< 0.0001^a
Borderline	95/279	1.47 (1.20-1.80)	0.0002^a	30/48	1.32 (0.92-1.89)	0.1343	0.90 (0.59-1.36)	0.6100
Perineural invasion			< 0.0001^a			< 0.0001^a
Negative	23417/75025	Reference		5061/8437	Reference
Positive	3845/7301	2.05 (1.98-2.12)	< 0.0001^a	3415/4659	1.46 (1.40-1.52)	< 0.0001^a	0.71 (0.68-0.75)	< 0.0001^a
Liver metastasis			< 0.0001^a			< 0.0001^a
No	24811/82821	Reference		5859/10377	Reference
Yes	5164/6443	4.73 (4.59-4.88)	< 0.0001^a	3242/3627	2.66 (2.54-2.78)	< 0.0001^a	0.56 (0.53-0.59)	< 0.0001^a
Lung metastasis			< 0.0001^a			< 0.0001^a
No	28622/87677	Reference		8225/13053	Reference
Yes	1297/1526	4.97 (4.70-5.25)	< 0.0001^a	822/893	2.40 (2.23-2.58)	< 0.0001^a	0.48 (0.44-0.53)	< 0.0001^a

^aP < 0.05.

TNM: Tumor, node and metastasis; CEA: Carcinoembryonic antigen; HR: Hazard ratio; TDs: Tumor deposits.

Citation: Wu WX, Zhang DK, Chen SX, Hou ZY, Sun BL, Yao L, Jie JZ. Prognostic impact of tumor deposits on overall survival in colorectal cancer: Based on Surveillance, Epidemiology, and End Results database. World J Gastrointest Oncol 2022; 14(9): 1699-1710
URL: https://www.wjgnet.com/1948-5204/full/v14/i9/1699.htm
DOI: https://dx.doi.org/10.4251/wjgo.v14.i9.1699