Prognostic impact of tumor deposits on overall survival in colorectal cancer: Based on Surveillance, Epidemiology, and End Results database

Table 2 Overall survival univariate and multivariate Cox models of baseline characteristics

	Univariate Cox models			Multivariate Cox model
	Events/total	HR (95%CI)	P value	Events/total	HR (95%CI)	P value
Sex			0.3665
Female	19008/50424	Reference
Male	20358/53331	1.01 (0.99-1.03)	0.3665
Race			< 0.0001a			< 0.0001a
White	30958/81034	Reference		27279/73091	Reference
Black	5049/12026	1.14 (1.11-1.17)	< 0.0001a	4440/10821	1.19 (1.16-1.23)	< 0.0001a
Others	3359/10695	0.80(0.77-0.83)	<.0001a	2926/9552	0.83(0.80-0.86)	<.0001a
Age group, yr			< 0.0001a			< 0.0001a
< 45	1866/6971	Reference		1627/6276	Reference
45-75	20956/68247	1.17 (1.11-1.22)	< 0.0001a	18394/61529	1.49 (1.42-1.57)	< 0.0001a
≥ 75	16544/28537	2.78 (2.65-2.92)	< 0.0001a	14624/25659	4.40 (4.17-4.63)	< 0.0001a
TNM-stage			< 0.0001a			< 0.0001a
Ι	4709/24927	Reference		4154/22321	Reference
ΙΙ	9334/30199	1.79 (1.73-1.85)	< 0.0001a	8362/27688	0.96 (0.89-1.02)	0.2060
ΙΙΙ	13498/34324	2.46 (2.38-2.55)	< 0.0001a	12086/31183	1.32 (1.21-1.43)	< 0.0001a
ΙV	11825/14305	9.08 (8.77-9.40)	< 0.0001a	10043/12272	3.27 (2.99-3.56)	< 0.0001a
T-stage			< 0.0001a			< 0.0001a
T1	2794/15661	Reference		2259/13476	Reference
T2	3477/14794	1.35 (1.29-1.42)	< 0.0001a	3167/13728	1.18 (1.12-1.25)	< 0.0001a
T3	21562/55544	2.52 (2.42-2.62)	< 0.0001a	19171/50529	1.71 (1.59-1.83)	< 0.0001a
T4	11533/17756	5.80 (5.57-6.05)	< 0.0001a	10048/15731	2.83 (2.63-3.05)	< 0.0001a
N-stage			< 0.0001a			< 0.0001a
N0	16014/57759	Reference		14081/52146	Reference
N1	12199/28709	1.73 (1.69-1.78)	< 0.0001a	10718/25885	0.96 (0.91-1.02)	0.1880
N2	11153/17287	3.38 (3.30-3.47)	< 0.0001a	9846/15433	1.44 (1.36-1.53)	< 0.0001a
M-stage			< 0.0001a
M0	27541/89450	Reference
M1	11825/14305	5.05 (4.94-5.16)	< 0.0001a
Liver metastasis			< 0.0001a			< 0.0001a
No	30670/93198	Reference		27418/84728	Reference
Yes	8406/10070	4.67(4.56-4.79)	< 0.0001a	7227/8736	1.33(1.28-1.39)	< 0.0001a
Lung metastasis			< 0.0001a			< 0.0001a
No	36847/100730	Reference		32838/91390	Reference
Yes	2119/2419	4.62 (4.42-4.83)	< 0.0001a	1807/2074	1.32 (1.25-1.38)	< 0.0001a
Site			< 0.0001a
Colon	32774/83476	Reference
Rectum	5782/18751	0.71 (0.69-0.73)	< 0.0001a
CEA			< 0.0001a
Normal	9708/35709	Reference
Elevated	14098/26641	2.46 (2.40-2.53)	< 0.0001a
Borderline	125/327	1.51 (1.26-1.80)	0.0001a
Perineural invasion			< 0.0001a			< 0.0001a
Negative	28478/83462	Reference		27655/81868	Reference
Positive	7260/11960	2.32 (2.26-2.38)	< 0.0001a	6990/11596	1.22 (1.19-1.26)	< 0.0001a
Tumor deposits			< 0.0001a			< 0.0001a
No	30165/89624	Reference		26523/80813	Reference
Yes	9201/14131	2.73 (2.67-2.80)	< 0.0001a	8122/12651	1.35 (1.31-1.38)	< 0.0001a

^aP < 0.05.

TNM: Tumor, node and metastasis; CEA: Carcinoembryonic antigen.