Profiling of gene fusion involving targetable genes in Chinese gastric cancer

Figure 3 Examples of novel gene fusions involving targetable genes in gastric cancer. A-D: Schematic representation and Integrative Genomics Viewer screenshot of FGFR2-PED2A (A), STIM-BRAF (B), OPALIN-RET (C), and NTRK2-ARHGAP10 (D) are shown; A and B: FGFR2 and BRAF fusions were confirmed by fluorescence in situ hybridization using FGFR2 (10q26) or BRAF (7q34) break-apart probes. Red spot: 5′ Probe signal; Green spot: 3′ probe signal; Yellow spot: Target gene without rearrangement. Arrows indicate the cells with separate 5′ (red) and 3′ (green) signals. Bar: 100 μm. TK: Tyrosine kinase domain.