Adjuvant chemoradiotherapy vs adjuvant chemotherapy in locally advanced Siewert type II/III adenocarcinoma of gastroesophageal junction after D2/R0 resection

Table 5 Univariate and multivariable cox proportional hazards modeling for overall survival in Siewert type III gastroesophageal junction

Clinicopathological features	Univariate analysis		Multivariable analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex
Male	Ref.
Female	0.573 (0.277-1.186)	P = 0.134
BMI
18.5-23.9	Ref.
< 18.5 or > 23.9	1.142 (0.755-1.728)	P = 0.530
The degree of differentiation
Poorly differentiated	Ref.
Moderately-highly differentiated	0.945 (0.592-1.509)	P = 0.813
Nerve invasion
Yes	Ref.		Ref.
No	0.086 (0.021-0.349)	P = 0.001	0.169 (0.037-0.774)	P = 0.022
Vascular invasion
Yes	Ref.		Ref.
No	0.041 (0.006-0.295)	P = 0.002	0.092 (0.012-0.689)	P = 0.020
Pathologic T stage
Group 1-3	Ref.		Ref.
Group 4a-4b	1.479 (0.975-2.242)	P = 0.065	1.151 (0.751-1.763)	P = 0.518
Pathologic N stage
Group 1-2	Ref.		Ref.
Group 3	1.983 (1.099-3.580)	P = 0.023	3.621 (0.380-34.469)	P = 0.263
Pathologic TNM stage
IIIA stage	Ref.		Ref.
IIIB stage	1.420 (0.759-2.656)	P = 0.273	1.801 (0.180-18.037)	P = 0.617
IIIC stage	2.783 (1.472-5.261)	P = 0.002	0.681 (0.434-1.069)	P = 0.095
Adjuvant chemoradiotherapy
Yes	Ref.		Ref.
No	2.465 (1.270-4.782)	P = 0.008	2.258 (1.145-4.453)	P = 0.019

BMI: Body mass index; HR: Hazard ratio; CI: Confidence interval.