Adjuvant chemoradiotherapy vs adjuvant chemotherapy in locally advanced Siewert type II/III adenocarcinoma of gastroesophageal junction after D2/R0 resection

Table 4 Univariate and multivariable cox proportional hazards modeling for overall survival in Siewert type II gastroesophageal junction

Clinicopathological features	Univariate analysis		Multivariable analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex
Male	Ref.
Female	0.683 (0.389-1.199)	P = 0.185
BMI
18.5-23.9	Ref.
< 18.5 or > 23.9	1.019 (0.657-1.581)	P = 0.931
The degree of differentiation
Poorly differentiated	Ref.
Moderately-highly differentiated	0.733 (0.437-1.227)	P = 0.237
Nerve invasion
Yes	Ref.		Ref.
No	0.083 (0.020-0.339)	P = 0.001	0.117 (0.028-0.500)	P = 0.004
Vascular invasion
Yes	Ref.		Ref.
No	0.215 (0.093-0.496)	P < 0.001	0.425 (0.178-1.014)	P = 0.054
Pathologic T stage
Group 1-3	Ref.		Ref.
Group 4a-4b	1.404 (0.899-2.194)	P = 0.136	1.271 (0.777-2.080)	P = 0.340
Pathologic N stage
Group 1-2	Ref.		Ref.
Group 3a-b	2.089 (1.137-3.721)	P = 0.012	1.027 (0.385-2.739)	P = 0.958
Pathologic TNM stage
IIIB stage	Ref.		Ref.
IVA stage	2.540 (1.267-5.091)	P = 0.009	2.081 (0.629-6.885)	P = 0.230
Adjuvant chemoradiotherapy
Yes	Ref.		Ref.
No	1.859 (0.956-3.614)	P = 0.068	1.877 (0.943-3.738)	P = 0.073

BMI: Body mass index; HR: Hazard ratio; CI: Confidence interval.