Poorly cohesive cells gastric carcinoma including signet-ring cell cancer: Updated review of definition, classification and therapeutic management

Table 5 Summary of studies reporting prognostic value of signet ring cell- and poorly cohesive cell-gastric cancer

Studies	n	n SRC (%)	% LNM	5-yr survival rate % (PCC-GC vs other)	Univariate	Multivariate	Compared to
Eastern studies
Maehara et al[49], 1992	1116	23 (2.1)	60.8	42.5 vs 37.6	NS	-	Non SRC-GC
Kim et al[177], 1994	2917	265 (9.1)	80.8	33 vs 45.4/38.8/35.3	P < 0.05	-	WD/MD/PD
Otsuji et al[178], 1998	930	60 (6.4)	63.3	44.4 vs 27.5 (10-yr survival rate)	NS	-	Non SRC-GC
Yokota et al[179], 1998	430	52 (12.1)	-	Worse	NS	-	Non SRC-GC
Kunisaki et al[185], 2004	600	54 (9.0)	57.4	Similar	NS	-	Non SRC-GC
Kim et al[180], 2004	1797	110 (6.1)	47.3	35.1 vs 39.5	NS	-	Non SRC-GC
Li et al[56], 2007	4759	662 (13.9)	75.7	42.4 vs 50.1	0.009	NS	Non SRC-GC
Chiu et al[182], 2011	1860	356 (19.1)	71.6	41.5 vs 46.3	P = 0.018	-	Non SRC-GC
Jiang et al[55], 2011	2046	157 (7.7)	64.3	31.5 vs 35.7	NS	NS	Non SRC-GC
Zu et al[57], 2014	741	44 (5.9)	56.8	43.4 vs 87.1/57.1/50.6/62.7	P = 0.012	0.028	WD/MD/PD/MC
Kwon et al[50], 2014	443	57 (12.9)	73.7	26.0 vs 50.5/38.4 (10-yr survival rate)	P = 0.044	NS	WD-MD/PD-MC
Chon et al[53], 2017	1777	555 (31.2)	-	53 vs 58/52 (10-yr survival rate)	P < 0.001	P < 0.001	WMD/PD
Western studies
Heger et al[58], 2014	723	235 (32.5)	63.0	26.3 vs 46.6 mo (median survival)	P < 0.001	P = 0.02 (backward analysis)	Non SRC-GC

EGC: Early gastric cancer; LNM: Lymph node metastasis; SRC-GC: Signet ring cell-gastric cancer; PCC-GC: Poorly cohesive cells-gastric cancer; WMD: Well-and moderately-differentiated gastric cancer; PD: Poorly differentiated; MC: Mucinous cancer; NS: Non-significant.