Poorly cohesive cells gastric carcinoma including signet-ring cell cancer: Updated review of definition, classification and therapeutic management

Table 4 Summary of studies reporting prognostic value of signet ring cell- and poorly cohesive cell-early gastric cancer

Ref.	n	n SRC-GC (%)	% LNM	5-yr survival rate %, SRC-GC vs other	Univariate	Multivariate	Compared to
Eastern studies
Maehara et al[49], 1992	384	28 (7.3)	10.7	100 vs 94.8	NS	-	Non SRC-GC
Kim et al[177], 1994	785	185 (23.6)	7.6	92.9 vs 83.9/87.3/93.6	NS	-	WD/MD/PD
Otsuji et al[178], 1998	568	94 (16.5)	5.3	93 vs 76.3	P < 0.05	-	Non SRC-GC
Yokota et al[179], 1998	253	41 (16.2)	-	Similar	NS	-	Non SRC-GC
Hyung et al[80], 2002	933	263 (28.2)	5.7	94.2 vs 91.6	P = 0.01	-	Non SRC-GC
Kim et al[180], 2004	561	94 (16.8)	2.1	96.3 vs 90.8	NS	NS	Non SRC-GC
Kunisaki et al[185], 2004	513	120 (23.4)	9.2	Better	P = 0.033	P = 0.036	Non SRC-GC
Ha et al[186], 2008	1520	388 (25.5)	9.5	99.7 vs 99.1/97.2	NS/P = 0.019	-	WMD-PA/PD-MC
Zhang et al[45], 2010	138	49 (35.5)	-	Similar	NS	-	Non SRC-GC
Chiu et al[182], 2011	579	149 (25.7)	10.7	96.1 vs 89.6	P = 0.01	-	Non SRC-GC
Jiang et al[55], 2011	269	54 (20.1)	16.7	94.3 vs 90.6	P = 0.007	P = 0.011	Non SRC-GC
Kwon et al[50], 2014	326	51 (15.6)	9.8	84.0 vs 76.0/65.7 (10-yr survival rate)	NS	-	WD-MD/PD-MC
Kim et al[52], 2014	2085	345 (16.5)	9.0%	Similar (disease-related survival)	NS	-	WD/MD/PD
Wang et al[187], 2015	334	115 (34.4)	8.5	93.9 vs 85.8	P = 0.027	0.001	UD
Chon et al[53], 2017	3272	1091 (33.3)	-	95 vs 85 (10-yr survival rate)	P < 0.001	P = 0.041 (WMD)	WMD-PD
Imamura et al[188], 2016	746	152 (20.4)	2.0	97.4 vs 89.9	P = 0.012	P = 0.038	Non SRC-GC
Western studies
Gronnier et al[54], 2013	421	104 (24.7)	24,0	85 vs 76	P = 0.035	NS	Non SRC-GC
Bamboat et al[51], 2014	437	174 (39.8)	-	0 vs 8/24 (5-disease-specific mortality)	P = 0.001	-	WMD/PD

EGC: Early gastric cancer; LNM: Lymph node metastasis; SRC-GC: Signet ring cells-gastric cancer; non SRC-GC: Gastric cancer other types than SRC-GC; WMD: Well-and moderately-differentiated gastric cancer; PD: Poorly differentiated; MC: Mucinous cancer; NS: Non-significant.