Poorly cohesive cells gastric carcinoma including signet-ring cell cancer: Updated review of definition, classification and therapeutic management

Table 3 Summary of studies reporting the all-stage prognostic value of signet ring cell- and poorly cohesive cell-gastric cancer

Ref.	n		n SRC-CG (%)		% LNM		5-yr survival rate %, SR-CGC vs other	Univariate	Multivariate	Compared to
Eastern studies
Maehara et al[49], 1992	1500		51 (3.4)		33.3		74.5 vs 52.4	P < 0.01	-	Non SRC-GC
Kim et al[177], 1994	3702		450 (12.2)		50.6		59.7 vs 57.7/48.6/43.1	NS	-	WD/MD/PD
Otsuji et al[178], 1998	1498		154 (10.3)		27.9		68.2 vs 43.9 (10-yr survival rate)	P < 0.05	-	Non SRC-GC
Yokota et al[179], 1998	923		93 (10.1)		43		Worse	NS	-	Non SRC-GC
Kim et al[180], 2004	2358		204 (8.7)		26.5		60.2 vs 48.9	P < 0.01	NS	Non SRC-GC
Park et al[181], 2008	2275		251 (11.0)		46.2		66.2 vs 66.7/54.5/51.0	WD: NS; PD/MC: P < 0.001	P = 0.002a	WD/PD/MC
Zhang et al[45], 2010	1439		218 (15.1)		76.1		44.9 vs 36	P = 0.013	NS	Non SRC-GC
Chiu et al[182], 2011	2439		505 (20.7)		53.7		57.6 vs 56	NS	-	Non SRC-GC
Jiang et al[55], 2011	1439		211 (14.7)		52,0		49.8 vs 41.4	P = 0.001	-	Non SRC-GC
Lee et al[176], 2012	1002		320 (31.9)		37.2		84.8 vs 71.9/57.8	P < 0.001	NS	PD/MC
Kwon et al[50], 2014	769		108 (14.0)		43.5		55.4 vs 64.5/46.2 (10-yr survival rate)	P < 0.001	NS	WD-MD/PD-MC
Liu et al[162], 2015	1464		138 (9.4)		30.4		36.2 vs 49.5	P < 0.001	P < 0.001	Non SRC-GC
Chon et al[53], 2017	7667		1646 (21.5)		25.8		80.0 vs 70.0 (10-y survival rate)	P < 0.001	NS	WMD/PD
Lu et al[183], 2016	2199		354 (16.1)		-		15.9 mo vs 22.1 mo	P = 0.002	< 0.001	Non SRC-GC
Western studies
Theuer et al[184], 1999	3020	453 (15.0)		NR		Similar		NS	NS	Non SRC-GC
Piessen et al[35], 2009	180	59 (32.8)		83.1		28 vs 46		P = 0.004	P = 0.004	Non SRC-GC
Taghavi et al[44], 2012	10246	2666 (26)		59.7		Similar (Disease-specific survival)		NS	P = 0.15	Non SRC-GC
Bamboat et al[51], 2014	569	210 (36.9)		61.0		49 vs 24/43 (5-y cumulative-mortality)		P < 0.0001	-	WMD/PD
Postlewait et al[6], 2015	768	312 (40.6)		66.3		33.7 mo vs 46.6 mo (OS)		P = 0.011	NS	Non SRC-GC
Voron et al[8], 2016	1799	899 (50)		73.2		26 mo vs 51 mo (median survival)		P < 0.001	P < 0.041	Non SRC-GC

^aThe survival rate of patients with stage IV signet ring cells-gastric cancer was poorer than those with the other three types.

LNM: Lymph node metastasis; SRC-GC: Signet ring cells-gastric cancer; non SRC-GC: gastric cancer other types than SRC-GC; WMD: Well-and moderately-differentiated gastric cancer; PD: Poorly differentiated; MC: Mucinous cancer; NS: Non-significant.