KIFC3 promotes proliferation, migration and invasion of esophageal squamous cell carcinoma cells by activating EMT and β-catenin signaling

Figure 6 KIFC3 promotes the progression of ESCC via β-catenin signaling. A: Western blotting showing that KIFC3 knockdown inhibits, while its overexpresssion promotes the expression of β-catenin in ESCC cells; B: Statistical analysis of the data presented in A; C: Immunofluorescence showing that KIFC3 knockdown inhibits, while its overexpression promotes the expression of β-catenin, scale bar: 20 μm; D: Inhibitor of β-catenin, XAV-939 is used to treat KYSE450oeNC and KYSE450oeKIFC3 cells, then western blotting is used to detect downstream molecules of β-catenin signaling; E: Statistical analysis of the data presented in D. ^aP < 0.05 vs the KYSE450oeNC group, ^bP < 0.05 versus the KYSE450oeNC+ XAV-939 group, ^cP < 0.05 vs the KYSE450oeKIFC3 group. ESCC: Esophageal squamous cell carcinoma; KIFC3: Kinesin family member C3.