KIFC3 promotes proliferation, migration and invasion of esophageal squamous cell carcinoma cells by activating EMT and β-catenin signaling

Figure 5 KIFC3 promotes migration, invasion, and EMT in human ESCC cells. A: Transwell migration assay showing that KIFC3 knockdown inhibits migration in KYSE150 cells, while its overexpression promotes migration in KYSE450 cells, scale bar: 20 μm; B: Transwell invasion assay showing that KIFC3 knockdown inhibits invasion in KYSE150 cells, while its overexpression promotes invasion in KYSE450 cells, scale bar: 20 μm; C: Statistical analysis of cell migration; D: Statistical analysis of cell invasion; E: Western blotting showing that KIFC3 knockdown inhibits epithelial-mesenchymal transition (EMT), while KIFC3 overexpression promotes EMT in ESCC cells; F: Statistical analysis of E. ^aP < 0.05 vs the KYSE150shNC group, ^bP < 0.05 vs the KYSE450oeNC group. ESCC: Esophageal squamous cell carcinoma; EMT: Epithelial–mesenchymal transition; KIFC3: Kinesin family member C3.