Efficacy of neoadjuvant chemotherapy for initially resectable colorectal liver metastases: A retrospective cohort study

Table 2 Prognostic factors for upfront hepatectomy

Variables		n	5-yr OS rate (%)	P value	Hazard ratio (95%CI)	P value
Patient-related
Age (yr)	< 60	60	65.7	0.24
	≥ 60	178	66.7
Sex	Male	167	66.5	0.28
	Female	71	65.8
CEA level (ng/mL)	< 10	122	75	0.01	1.948 (1.252–3.031)	0.003
	≥ 10	116	58.4
Primary tumor-related
Site	Left	190	56.2	0.14
	Right	48	68.5
Histology	Well/moderately differentiated	234	67.1	0.01	2.971 (1.038–8.503)	0.04
	Others	4	25
Lymph node metastases	0	108	79	0.001	1.623 (1.020–2.583)	0.04
	≥ 1	130	56.6
Depth of invasion	Adjacent organ invasion (T4b)	19	64.8	0.64
	Others	219	66.4
Lymphatic invasion	0	116	73.1	0.02	1.418 (0.897–2.242)	0.135
	≥ 1	122	60.8
Venous invasion	0	81	69.7	0.73
	≥ 1	157	63.9
Number	1–3	228	67.5	0.07
	≥ 4	10	38.1
Maximum diameter (mm)	< 40	180	70.9	0.05
	≥ 40	58	52.9
Timing of the appearance	Synchronous	54	61.2	0.94
	Metachronous	184	67.8
Distribution	Unilobar	198	67.1	0.12
	Bilobar	40	63
Treatment-related
Staged hepatectomy	Performed	0	–	–
	Not performed	238	66.3
Surgical margins	Exposed	19	40.1	0.09
	Not exposed	219	69
Adjuvant chemotherapy after primary resection	Administered	69	64.9	0.16
	Not administered	169	66.7
Adjuvant chemotherapy after hepatectomy	Administered	126	56.2	0.02	0.646 (0.414–1.009)	0.05
	Not administered	112	71.7

CEA: Carcinoembryonic antigen; CI: Confidence interval; OS: Overall survival.