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©The Author(s) 2022.
World J Gastrointest Oncol. Jul 15, 2022; 14(7): 1265-1280
Published online Jul 15, 2022. doi: 10.4251/wjgo.v14.i7.1265
Published online Jul 15, 2022. doi: 10.4251/wjgo.v14.i7.1265
Table 1 Gene expression profiles of GSE14323, GSE36411 and GSE89377 have 45 differentially expressed genes, including 2 downregulated genes and 43 upregulated genes in the fibrotic liver compared to normal liver
| DEGs | Genes | ||
| Upregulated | C-X-C chemokine receptor type 4 (CXCR4) | SH3 domain-containing YSC84-like protein 1 (SH3YL1) | Laminins containing the α2 (LAMA2) |
| Lumican (LUM) | DNA-binding protein inhibitor ID-3 (ID3) | Microfibril-associated glycoprotein 4 (MFAP4) | |
| Prostaglandin-H2 D-isomerase (PTGDS) | Aldo-keto reductase family 1 member B10 (AKR1B10) | Marginal zone B- and B1-Cell-specific protein (MZB1) | |
| Dickkopf-related protein 3 (DKK3) | Ras-related protein Rac2 (RAC2) | Suppressor of lin-12-like protein 3 (SEL1L3) | |
| Dermatopontin (DPT) | Annexin A13 (ANXA13) | Defensin Beta 1 (DEFB1) | |
| H-2 class II histocompatibility antigen gamma chain (CD74) | CAMPATH-1 antigen (CD52) | Protein unc-93 homolog A (UNC93A) | |
| FXYD domain-containing ion transport regulator 2 (FXYD2) | Adipocyte enhancer-binding protein 1 (AEBP1) | Interleukin-7 receptor subunit alpha (IL7R) | |
| C-X-C motif chemokine 9 (CXCL9) | C-X-C motif chemokine 10 (CXCL10) | Ribonuclease pancreatic (RNASE1) | |
| SRY-Box transcription factor 9 (SOX9) | Gelsolin (GSN) | Carbohydrate sulfotransferase 4 (CHST4) | |
| Vimentin (VIM) | Galectin-3-binding protein (LGALS3BP) | Platelet-derived growth factor receptor alpha (PDGFRA) | |
| Lectin, galactoside-binding soluble 4 (LGALS4) | Laminin subunit gamma-3 (LAMC3) | Claudin-10 (CLDN10) | |
| Joining chain of multimeric IgA and IgM (JCHAIN) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2) | Cholesterol 25-hydroxylase (CH25H) | |
| Apolipoprotein L3 (APOL3) | Decorin (DCN) | Complement component C7 (C7) | |
| Epithelial cell adhesion molecule (EPCAM) | Keratin type I cytoskeletal 23 (KRT23) | EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) | |
| Matrix metallopeptidase 7 (MMP7) | |||
| Downregulated | Small conductance calcium-activated potassium channel protein 2 (KCNN2) | Cytochrome P450 2C19 (CYP2C19) | |
- Citation: Li Y, Yuan SL, Yin JY, Yang K, Zhou XG, Xie W, Wang Q. Differences of core genes in liver fibrosis and hepatocellular carcinoma: Evidence from integrated bioinformatics and immunohistochemical analysis. World J Gastrointest Oncol 2022; 14(7): 1265-1280
- URL: https://www.wjgnet.com/1948-5204/full/v14/i7/1265.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v14.i7.1265