Clinicopathological differences, risk factors and prognostic scores for western patients with intestinal and diffuse-type gastric cancer

Table 1 Univariate analyses: Differences between intestinal and diffuse subtypes (Chi-squared and Student’s t tests)

Feature	P value	OR, diffuse (95%CI)1
Age	< 0.001
Depth	0.004
Macroscopic type	0.001
Polypoid		0.86 (0.45-1.65)
Flat		3.16 (1.49-6.71)
Ulcerative		1.54 (0.9-2.65)
Fungoid		0.38 (0.21-0.69)
Local symptoms	0.004	0.4 (0.2-0.75)
Necrosis	0.006	0.39 (0.2-0.77)
Perineural infiltration	< 0.001	2.98 (1.78-5)
Intratumoral inflammation	0.054
No		0.63 (0.28-1.38)
Mild		2.08 (1.07-4.03)
High		0.68 (0.38-1.2)
Desmoplasia	< 0.001	0.29 (0.16-0.54)
Microsatellite instability	0.023	0.16 (0.02-0.28)
HERCEPTEST 2+/3+	0.018	0.07 (0.02-0.24)
T stage	0.02
T1		0.41 (0.19-0.88)
T2		0.74 (0.39-1.4)
T3		1.25 (0.76-2.05)
T4		2.08 (1.08-3.99)
N stage	0.02
N0		0.5 (0.3-0.85)
N1		0.8 (0.4-1.6)
N2		1.93 (1.04-3.55)
N3		1.62 (0.9-2.93)
Metastatic lymph nodes	0.005
Lymph node ratio	< 0.001
Adjuvant therapy	0.022	2.14 (1.11-4.15)
Recurrence	< 0.001	2.63 (1.55-4.47)
Death	< 0.001	2.82 (1.56-5.09)

¹Odds ratios have been calculated for diffuse vs intestinal subtype.