Review
Copyright ©The Author(s) 2022.
World J Gastrointest Oncol. Jun 15, 2022; 14(6): 1067-1085
Published online Jun 15, 2022. doi: 10.4251/wjgo.v14.i6.1067
Table 1 Roles of circular RNAs in hepatocellular carcinoma
circRNAs
Dysregulation
Mechanism by competitively binding miRNAs/RBP or m6A modification/mRNA braking
Targets/signaling pathways
Biological functions
Ref.
circRNA ZFRUp-regulatedN/AMAP2K1Promotes HCC proliferationCedric et al[50]
miR-3619-5pCTNNB1 Wnt/β-catenin pathwayPromotes HCC proliferation and EMTTan et al[99]
hsa_circ_0091581Up-regulatedmiR-526bc-MycPromotes HCC proliferationWei et al[53]
circ_0000517Up-regulatedmiR-1296-5pTXNDC5Promotes HCC growth and inhibits cell cycle arrest and apoptosisZang et al[55]
miR-326SMAD6Promotes HCC invasion and metastasisHe et al[67]
circSETD3Down-regulatedmiR-421MAPK14Inhibits HCC proliferation and induces G1/S arrestXu et al[57]
N/AN/APredicts MVI of HCCWang et al[85]
Exosomal circ-0051443Down-regulatedmiR-331-3pBAK1Promotes HCC cell apoptosis and arrests the cell cycleChen et al[58]
cicrRNA_101368Up-regulatedmiR-200aHMGB1/RAGE pathwayPromotes HCC cell migrationLi et al[60]
circ-CCND1Up-regulatedmiR-497-5pHMGA2Promotes HCC proliferation, migration and invasionZheng et al[61]
hsa_circ_0061395Up-regulatedmiR-877-5pPIK3R3Promotes HCC proliferation, migration and invasionYu et al[62]
miR-656-3pSERBP1Li et al[63]
circRNA-103809Up-regulatedmiR-377-3pFGFR1/ERK Facilitates HCC migration, invasion and EMTZhan et al[64]
miR-1270PLAGL2Cao et al[65]
circ_MMP2Up-regulatedmiR-136-5pMMP2Promotes HCC metastasisLiu et al[68]
circ-MALAT1Up-regulatedmRNA brakingPAX5Promotes self-renewal of HCC stem cellsChen et al[69]
miR-6887-3pJAK2
circZKSCAN1Down-regulatedRBP: FMRPCCAR1, Wnt/β-catenin pathwayInhibits HCC stem cell activityZhu et al[70]
circMEG3Down-regulatedm6A-METTL3HULC and Cbf5Inhibits malignant differentiation of human liver CSCsJiang et al[71]
circ-PRKCI Up-regulatedmiR-1294 and miR-186-5pFOXK1Promotes HCC glycolysisChen et al[73]
circZFRUp-regulatedmiR-375HMGA2Promotes HCC glycolysisXu et al[75]
circMAT2BUp-regulatedmiR-338-3pPKM2Promotes HCC glycolysisLi et al[77]
circ-PRMT5Up-regulatedmiR-188-5pHK2Enhances HCC glycolysisDing et al[79]
circ_0001445Down-regulatedmiR-942-5pALX4Inhibits HCC metastasis and EMTXu et al[81]
ciRS-7Up-regulatedmiR-7PIK3CD/p70S6K/mTOR pathwayPredicts hepatic MVIXu et al[83]
hsa_circ_0068669Down-regulatedN/AN/APredicts hepatic MVIYao et al[84]
circCRIM1Up-regulatedmiR-378a-3pSKP2Promotes HCC angiogenesisJi et al[86]
hsa-circ-0046600Up-regulatedmiR-640HIF-1αPromotes HCC angiogenesisZhai et al[87]
hsa_circ_0000092Up-regulatedmiR-338-3pHN1Promotes HCC angiogenesisPu et al[89]
circGFRA1Up-regulatedmiR-149N/APromotes HCC angiogenesisYu et al[91]
circARSP91Down-regulatedN/AULBP1Enhances HCC innate immune surveillanceMa et al[93]
circTRIM33-12Down-regulatedmiR-191TET1Inhibits HCC immune escape Zhang et al[96]
hsa_circ0007456Down-regulatedmiR-6852-3pICAM-1Inhibits HCC immune escapeShi et al[97]
hsa_circ_104348Up-regulatedmiR-187-3pRTKN2 Wnt/β-catenin pathwayPromotes HCC resistance to sorafenibHuang et al[100]
circβ-cateninUp-regulatedTranslationWnt/β-catenin pathwayFacilitates HCC cell growthLiang et al[101]
hsa_circ_0004018Down-regulatedmiR-626DKK3 Wnt/β-catenin pathwayRestrains HCC proliferation and migration Zhu et al[102]
circRNA-ITCHDown-regulatedmiR-7 or miR-214c-myc and cyclinD1Wnt/β-cateninInhibits HCC proliferation and apoptosisYang et al[103]
circ-0003418Down-regulatedmiR-7 and miR-383Wnt/β-catenin pathwayIncreases HCC sensitivity to cisplatinChen et al[104]
circ-IGF1RUp-regulatedN/API3K/AKT pathwayPromotes HCC cell proliferationFu et al[106]
hsa_circ_0079299Down-regulatedN/ACCNB1PI3K/Akt/mTOR pathwayInhibits HCC growthZheng et al[107]
circSOD2Up-regulatedmiR-502-5pDNMT3A JAK2/STAT3 pathwayPromotes HCC growth, cell migration and cell cycle progressionZhao et al[108]
circ_0004913Down-regulatedmiR-184HAMP JAK2/STAT3/Akt pathwayInhibits HCC proliferation, migration, invasion, EMT and glycolysisWu et al[109]
N/AN/APredicts better prognosis of HCCLi et al[150]
circ_0031242Up-regulatedmiR-924POU3F2Enhances HCC resistance to cisplatinFan et al[112]
circARNT2Up-regulatedmiR-155-5pPDK1Promotes HCC resistance to cisplatinLi et al[115]
circ-G004213Down-regulatedmiR-513b-5pPRPF39Facilitates HCC sensitivity to cisplatinQin et al[117]
circUBE2D2Up-regulatedmiR-889-3pLDHAPromotes HCC resistance to sorafenibHuang et al[121]
circFN1Up-regulatedmiR-1205E2F1Facilitates HCC resistance to sorafenibYang et al[122]
circRNA-SOREUp-regulatedRBP: YBX1AKT, Raf1, ERK, c-Myc, and TGF-β1Promotes HCC resistance to sorafenibXu et al[124]
circMEMO1Down-regulatedmiR-106b-5pTCF21Increases HCC sensitivity to sorafenibDong et al[126]
circUHRF1Up-regulatedmiR-449C-5pTIM-3Promotes HCC resistance to PD1 immunotherapyZhang et al[131]
circMETUp-regulatedmiR-30-5pSnail/DPP4/CXCL10 axisPromotes HCC resistance to PD1 immunotherapyHuang et al[133]
Exosomal circ_0070396Up-regulatedN/AN/AServes as a biomarker of early diagnosis of HCCLyu et al[139]
circ_104075Up-regulatedmiR-582-3pYAPServes as a biomarker of early diagnosis of HCCZhang et al[140]
has_circ _00224 and hsa_circ _00520Up-regulatedN/AN/AServes as biomarkers of early diagnosis of HCC with HCV infectionMatboli et al[141]
hsa_circ_0000976Up-regulatedN/AN/AServes as biomarkers of early diagnosis of HCC with HBV infectionYu et al[142]
hsa_circ_0007750
hsa_circ_0139897
hsa_circ_0091579Up-regulatedN/AGPC3Predicts poorer prognosis of HCCZhang et al[144]
circ_0000798 N/A N/ALei et al[145]
circ_0000267Up-regulatedmiR-646N/APredicts poorer prognosis of HCCPan et al[146]
circASAP1miR-326, miR-532-5pMAPK1Hu et al[147]
circ-ZNF652Up-regulatedmiR-203/miR-502-5pSnail-mediated EMTPredicts poorer prognosis of HCCGuo et al[148]
hsa_circ_0001649Down-regulatedN/AN/APredicts better prognosis of HCCZhang et al[149]
circSETD3Down-regulatedmiR-421MMP1Predicts better prognosis of HCCXu et al[57]
hsa_circ_0036683N/AN/ASunagawa et al[151]
hsa_circ_0005986Down-regulatedN/AN/APredicts better prognosis of HCCKim et al[152]